1. Epigenetics
  2. Histone Acetyltransferase
  3. P300/CBP-IN-6

P300/CBP-IN-6 

Cat. No.: HY-136285
Handling Instructions

P300/CBP-IN-6 is a p300/CBP histone acetyltransferase (HAT) inhibitor extracted from patent WO2019161162A1, compound 33, has an IC50 of 330 nM for p300 HAT.

For research use only. We do not sell to patients.

P300/CBP-IN-6 Chemical Structure

P300/CBP-IN-6 Chemical Structure

CAS No. : 2374971-81-8

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Description

P300/CBP-IN-6 is a p300/CBP histone acetyltransferase (HAT) inhibitor extracted from patent WO2019161162A1, compound 33, has an IC50 of 330 nM for p300 HAT[1].

IC50 & Target

IC50: 330 nM (p300 HAT)[1]

In Vitro

Histone acetyltransferases (HATs) catalyze the acetylation (transfer of an acetyl group) on a e-amino group of a target lysine side chain within a substrate histone, and histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysine residues. Subsequently, acetylated core histones were shown to preferentially associate with transcriptionally active chromatin. HATs are categorized into four major families based on primary sequence homology, shared structural features, and functional roles: Gcn5/PCAF (General control nonrepressed protein 5 and p300 and CBP associated factor); MYST (named for the founding members MOZ, Ybf2/Sas3, Sas2, and Tip60); p300/CBP (protein of 300kDa and CREB Binding Protein); and Rttl09 (Regulator of Tyl Transposition gene production 109)[1].

Molecular Weight

450.53

Formula

C₂₇H₂₆N₆O

CAS No.

2374971-81-8

SMILES

O=C(NC1=NC=C(C2=CN(C)N=C2)C=C1)[[email protected]](NC[[email protected]](C3=CC=C(C#N)C=C3)C)C4=CC=CC=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

P300/CBP-IN-6Histone AcetyltransferaseHATsHATP300CBPacetylationCREBHDACInhibitorinhibitorinhibit

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