2. Epigenetics
  3. Histone Acetyltransferase
  4. Procyanidin B3

Procyanidin B3 

Cat. No.: HY-N2345 Purity: 99.63%
COA Handling Instructions

Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase).

For research use only. We do not sell to patients.

Procyanidin B3 Chemical Structure

Procyanidin B3 Chemical Structure

CAS No. : 23567-23-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 755 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 755 In-stock
Solid
1 mg USD 229 In-stock
5 mg USD 686 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].

IC50 & Target

p300[1]
Molecular Weight

578.52

Appearance

Solid

Formula

C30H26O12
CAS No.
SMILES

O[[email protected]@H]1[[email protected]@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3[[email protected]]1C4=C5C(C[[email protected]](O)[[email protected]@H](C6=CC=C(O)C(O)=C6)O5)=C(O)C=C4O
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (86.43 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7285 mL 8.6427 mL 17.2855 mL
5 mM 0.3457 mL 1.7285 mL 3.4571 mL
10 mM 0.1729 mL 0.8643 mL 1.7285 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.63%

COA (258 KB) HNMR (313 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Procyanidin B323567-23-9Procyanidin B 3Procyanidin B-3Histone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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