Cat. No.: HY-N2342

Procyanidin C1

(Synonyms: PCC1)

10 Cited Publications

Customer Review

Based on 10 publication(s) in Google Scholar

Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice.

For research use only. We do not sell to patients.

Purity: 99.54%
CAS No.: 37064-30-5
Formula: C₄₅H₃₈O₁₈
Molecular Weight:866.77

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Procyanidin C1 Chemical Structure

CAS No.: 37064-30-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (10)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 31.5 μg/mL (MCF-7), 36.6 μg/mL (MDA-MB-231)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	>10 μg/mL Compound: 49	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	>10 μg/mL Compound: 49	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	>10 μg/mL Compound: 49	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
MT4	CC₅₀	16.5 μg/mL Compound: 10, proanthocyanidin C1	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 10425115]
MT4	IC₅₀	4.3 μg/mL Compound: 10, proanthocyanidin C1	Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 10425115]
TE-671	ED₅₀	>10 μg/mL Compound: 49	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]

In Vitro

Procyanidin C1 (6.25-100 μg/mL; 48 h) shows cytotoxic activities to MCF-7 and MDA-MB-231 cells^[1].
Procyanidin C1 (35 μg/mL; 48 h) affects cell cycle of MCF-7 and MDA-MB-231 cancer cells^[1].
Procyanidin C1 significantly up-regulates Chk 1 and Chk 2 in MCF-7 and MDA-MB-231 cancer cells^[1].
Procyanidin C1 (27.85 and 66.41 μL) induces significant DNA damage in MCF-7 and MDA-MB-231 cancer cells^[1].
Procyanidin C1 (45 μg/mL; 72 h) reduces the expression level of Bcl-2 but increases the expression level of BAX, and increases activities of caspase 3 and 9 to induces cell apoptosis of MCF-7 and MDA-MB-231 cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 and MDA-MB-231 cell lines
Concentration:

35 μg/mL
Incubation Time:

48 h
Result:

Induced the cell cycle arrest at the S-phase in MCF-7 and MDA-MB-231 cell lines.

Cell Cytotoxicity Assay^[1]

Cell Line:

MCF-7 and MDA-MB-231 cell lines
Concentration:

6.25-100 μg/mL
Incubation Time:

48 h
Result:

Inhibited cell proliferation of MCF-7 and MDA-MB-231 cells with IC₅₀ values of 31.5 and 36.6 μg/mL and showed a higher cytotoxic activity to MDA-MB-231 than tamoxifen.

In Vivo

Procyanidin C1 (20 mg/kg; i.p.; 2 weeks after the first MIT dose and then delivered biweekly) increases tumour regression^[2].
Procyanidin C1 (20 mg/kg; i.p.; for 7 d) shows senolytic efficacy in mice with senescent mouse embryonic fibroblasts injection^[2].
Procyanidin C1 (20 mg/kg; p.o.; for 3 d) increases the lifespan of old mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Non-obese diabetes and severe combined immunodficiency mice with PSC27 and PC3 cancer cells injection, and pre-treated with mitoxantrone (MIT)^[2]
Dosage:

20 mg/kg
Administration:

Intraperitoneal injection; 20 mg/kg; 2 weeks after the first MIT dose and then delivered biweekly
Result:

Remarkably enhanced tumour regression (55.2% reduction in tumour size compared with MIT alone; 74.9% reduction in tumour volume compared with the placebo treatment) and depleted the majority of senescent cells in chemotherapy treated animals.

Animal Model:

24-27 months of age mice (both sexes)^[2]
Dosage:

20 mg/kg
Administration:

Oral gavage; 20 mg/kg; for three consecutive days
Result:

Enhanced the median post-treatment lifespan with 64.2% and decreased the mortality hazard than the vehicle-treated group.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 37064-30-5
Appearance Solid
Molecular Weight 866.77
Formula C₄₅H₃₈O₁₈
Color Light yellow to yellow
SMILES

OC1=C2C(O[C@H](C3=CC(O)=C(O)C=C3)[C@H](O)[C@H]2C4=C5C(C[C@@H](O)[C@@H](C6=CC(O)=C(O)C=C6)O5)=C(O)C=C4O)=C([C@H]7C8=C(O)C=C(O)C=C8O[C@H](C9=CC(O)=C(O)C=C9)[C@@H]7O)C(O)=C1
Synonyms

PCC1
Structure Classification
- Flavonoids
- Biflavones
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (10)

All RT-PCRCell Proliferation/Viability AssayCell Migration/Invasion AssayIn Vivo Efficacy Study

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Journal Impact Factor

Nat Aging

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance. [Abstract]

2026 Feb;6(2):316-328. PMID: 41611832
J Adv Res

Procyanidin C1 inhibits tumor growth and metastasis in colon cancer via modulating miR-501-3p/HIGD1A axis. [Abstract]

2024 Jun:60:215-231. PMID: 37479180

Procyanidin C1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jun:60:215-231. [Abstract]

Procyanidin C1 (PCC1) affected the level of hsa-miR-501-3p.

Procyanidin C1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jun:60:215-231. [Abstract]

The subsequent experiments showed that Procyanidin C1 (PCC1, 5-10 μM, 24-72 h) inhibited CRC cells proliferation in a dose- and time-dependent manners.

Procyanidin C1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jun:60:215-231. [Abstract]

In addition to proliferation, the effects of Procyanidin C1 (PCC1, 5-10 μM, 0-48 h) on cell migration and invasion were observed by using wound healing assays. The results showed that PCC1 inhibited the migration and invasion of DLD1 and HCT116 compared with the control groups.

Procyanidin C1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jun:60:215-231. [Abstract]

In addition to proliferation, the effects of Procyanidin C1 (PCC1, 5-10 μM) on cell migration and invasion were observed by using transwell assays. The results showed that PCC1 inhibited the migration and invasion of DLD1 and HCT116 compared with the control groups.

Procyanidin C1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jun:60:215-231. [Abstract]

To investigate whether the results of in vitro experiments were also observed in the in vivo experiments, mice were inoculated with cells, and CDDP (2 mg/kg and 4 mg/kg via i.p. injection) or Procyanidin C1 (PCC1, 20 mg/kg and 40 mg/kg via i.p. injection) was injected, then the weight and volume of tumors were measured respectively. The results showed that PCC1 significantly inhibited tumor weight and volume compared with the control group, although it was less effective than CDDP.
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Clin Transl Med

The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas. [Abstract]

2023 Dec;13(12):e1516. PMID: 38148640
J Agric Food Chem

High-Pressure and Thermal Pasteurization Applied to Smoothies Enhances (Poly)Phenol Bioaccessibility along the Gastrointestinal Tract. [Abstract]

2025 Jun 25;73(25):15561-15578. PMID: 40497562
Food Biosci

2026 Apr 15;80:108917.
Foods

Design of a Plant-Based Smoothie: Exploiting Ingredient Complementarity for a Diversified (Poly)phenolic Profile Quantified by Targeted LC-MS/MS Analysis. [Abstract]

2026 Apr 9;15(8):1293. PMID: 42073181
Bioorg Chem

Investigation of tyrosinase inhibitory components in Camellia reticulata and the inhibitory mechanism, binding behavior of TeGG to tyrosinase. [Abstract]

2026 Aug 5:177:109914. PMID: 42060987
FASEB J

Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells. [Abstract]

2025 Jan 31;39(2):e70362. PMID: 39878685
Research Square Print

January 3rd, 2023.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (115.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (115.37 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1537 mL

5.7685 mL

11.5371 mL

5 mM

0.2307 mL

1.1537 mL

2.3074 mL

10 mM

0.1154 mL

0.5769 mL

1.1537 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 6.25 mg/mL (7.21 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koteswari LL, et al. A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer. Nat Prod Res. 2019 Jan 8:1-8. [Content Brief]

[2]. Xu Q, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab. 2021 Dec;3(12):1706-1726. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	1.1537 mL	5.7685 mL	11.5371 mL	28.8427 mL
	5 mM	0.2307 mL	1.1537 mL	2.3074 mL	5.7685 mL
	10 mM	0.1154 mL	0.5769 mL	1.1537 mL	2.8843 mL
	15 mM	0.0769 mL	0.3846 mL	0.7691 mL	1.9228 mL
	20 mM	0.0577 mL	0.2884 mL	0.5769 mL	1.4421 mL
	25 mM	0.0461 mL	0.2307 mL	0.4615 mL	1.1537 mL
	30 mM	0.0385 mL	0.1923 mL	0.3846 mL	0.9614 mL
	40 mM	0.0288 mL	0.1442 mL	0.2884 mL	0.7211 mL
	50 mM	0.0231 mL	0.1154 mL	0.2307 mL	0.5769 mL
	60 mM	0.0192 mL	0.0961 mL	0.1923 mL	0.4807 mL
	80 mM	0.0144 mL	0.0721 mL	0.1442 mL	0.3605 mL
	100 mM	0.0115 mL	0.0577 mL	0.1154 mL	0.2884 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Procyanidin C1

10 Cited Publications

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Procyanidin C1

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Publications Citing Use of MedChemExpress (MCE) Procyanidin C1

Biological Activity

Chemical Information

Publications (10)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Procyanidin C1 Related Classifications

HY-N2342 Related Classifications