1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Procyanidin B1 

Cat. No.: HY-N0795 Purity: 99.92%
Handling Instructions

Procyanidin B1 , inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with IC50 of 29μM and 15μM, respectively.

For research use only. We do not sell to patients.

Procyanidin B1 Chemical Structure

Procyanidin B1 Chemical Structure

CAS No. : 20315-25-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 993 In-stock
Estimated Time of Arrival: December 31
1 mg USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 780 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of Procyanidin B1:

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  • Technical Information

  • Purity & Documentation

  • References

Description

Procyanidin B1 , inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with IC50 of 29μM and 15μM, respectively. IC50:29μM and 15μM(VSV/HCV infection)[3] In vitro: Procyanidin B1 can bind to the TLR4–MD-2 heterodimer through a competitive interaction with LPS, which suppresses the activation of NF-κB and p38 MAPK pathways. This provide a new insight into the role of procyanidin B1 as an antagonist of the immune response involved in the development and progression of many inflammatory diseases.[1] Procyanidin B1 (PB1), a dimer of (?)-epicatechin and (+)-catechin,suppresses HCV RNA synthesis, possibly as a HCV RNA polymerase inhibitor.No inhibitory effects were observed in each component of PB1. We found that PB1 does not interfere with viral entry or receptor expression, but inhibits HCV RNA synthesis in a dose-dependent manner.[3]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7285 mL 8.6427 mL 17.2855 mL
5 mM 0.3457 mL 1.7285 mL 3.4571 mL
10 mM 0.1729 mL 0.8643 mL 1.7285 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

578.52

Formula

C₃₀H₂₆O₁₂

CAS No.

20315-25-7

SMILES

O[[email protected]]1[[email protected]@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3[[email protected]@H]1C4=C5C(C[[email protected]](O)[[email protected]@H](C6=CC=C(O)C(O)=C6)O5)=C(O)C=C4O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Procyanidin B1
Cat. No.:
HY-N0795
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Procyanidin B1

Cat. No.: HY-N0795