Resveratrol (Synonyms: trans-Resveratrol; SRT501)

Cat. No.: HY-16561 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

For research use only. We do not sell to patients.

Resveratrol Chemical Structure

CAS No. : 501-36-0

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10 mM * 1 mL in DMSO	USD 73	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 72 publication(s) in Google Scholar

Other Forms of Resveratrol:

cis-Resveratrol In-stock

56 Publications Citing Use of MCE Resveratrol

: Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]; Resveratrol (RES) (10 mg/kg/day; intraperitoneally injected every day for 5 weeks) administration recoveres DOX-reduced expression of SIRT1 in hearts of Sirt1flox/flox mice.

: Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]; Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. Representative images of DHE (red) staining and quantification of the corresponding fluorescence intensity in H9c2 cells.

: Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310. [Abstract]; Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. The protein expression of SIRT1, SESN2, P-AMPKα, AMPKα and cleaved caspase-3 was detected by western blot analysis with densitometric quantification of each group.

: Resveratrol purchased from MCE. Usage Cited in: PLoS Biol. 2022 Jun 30;20(6):e3001682. [Abstract]; Immunostaining and brightfield of embryos either untreated or treated with solvent or with Resveratrol (1 μM).

: Resveratrol purchased from MCE. Usage Cited in: Biomed Pharmacother. 2022 Jun;150:113071.; EX527 antagonizes the protective effect of NRH on Kanamycin-induced hair-cell loss by inhibition of SIRT1, while Resveratrol (RSV; 10 μM) alleviates hair-cell damage caused by EX527.

: Resveratrol purchased from MCE. Usage Cited in: Cells. 2022 Jul 29;11(15):2331.; The depletion of HSF1 significantly decreased the reactivation efficiencies of Resveratrol.

: Resveratrol purchased from MCE. Usage Cited in: Cell Death Dis. 2021 Nov 29;12(12):1115. [Abstract]; Western blot and quantification for MICU3 in C2C12 cells treated with d-gal and Resveratrol (50 μM).

: Resveratrol purchased from MCE. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240. [Abstract]; Representative images of Rhodamine and DHE of treated BMSCs after indicated treatment.

: Resveratrol purchased from MCE. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240. [Abstract]; The expression levels of SIRT3, RUNX2, OCN in BMSCs after indicated treatment are analyzed by western blot.

: Resveratrol purchased from MCE. Usage Cited in: Cell Prolif. 2021 Mar;54(3):e12991. [Abstract]; Representative immunoblots of Ac p53 K381, total p53, progerin, Lamin A/C and Lamin B1 of primary HSECs on Day 2 in four groups (CTR, H2O2, H2O2 + Resveratrol, Resveratrol (1 μM; 2 days)).

: Resveratrol purchased from MCE. Usage Cited in: ACS Infect Dis. 2021 Apr 9;7(4):777-789. [Abstract]; Effects of Resveratrol on meningitic E. coli-induced ERK1/2 activation as well as VEGFA upregulation in hBMECs. By pretreatment with Resveratrol, the phosphorylation of ERK1/2 induced by meningitic E. coli in hBMECs is significantly reduced. Similarly, the upregulation of VEGFA also decreased considerably in a dose-dependent manner in resveratrol-treated hBMECs.

: Resveratrol purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251. [Abstract]; Resveratrol (50 mg/kg; i.p.; for 2 weeks) has no effect on body weight and kidney index in mice, but it significantly reduces FBG, BUN, and CR.

: Resveratrol purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251. [Abstract]; Western blotting demonstrates that Resveratrol (50 mg/kg; i.p.; for 2 weeks) increases the expression of E-Ca and ZO-1 and decreases the expression of α-SMA, vimentin, snail, and twist.

: Resveratrol purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]; HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

: Resveratrol purchased from MCE. Usage Cited in: J Agric Food Chem. 2017 Jun 7;65(22):4384-4394. [Abstract]; Resveratrol activates the HSF1 signaling pathway. J-Lat A2 cells are treated with various concentrations of Resveratrol or Carfilzomib (50 nM) for 48 h. Then the cells are lysed and Ser320 phosphorylated HSF1 and total HSF1 are detected by Western blot with corresponding antibodies.

: Resveratrol purchased from MCE. Usage Cited in: Chinese Journal of Cell Biology. 2015, 37(11):1522-1527.; Effect of Resveratrol on SIRT1 expression in HK-2 cells.

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator^[1]^[2]^[3]^[4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor^[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model^[6]. Resveratrol increases production of NO in endothelial cells^[7].

IC₅₀ & Target^[1]

Adenylyl cyclase

0.8 nM (IC₅₀)

IKKβ

1 μM (IC₅₀)

DNA polymerase α

3.3 μM (IC₅₀)

DNA polymerase δ

5 μM (IC₅₀)

Autophagy

Mitophagy

Sirtuin

In Vitro

Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported^[1].
MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled every 30 hr. Trypan blue exclusion assay shows that at concentrations of 10 μM or lower, Resveratrol does not affect cell viability (90% viable cells) whereas at 100 μM, only 50% of the cells are viable after 6 days of Resveratrol treatment. Moreover, MCF-7 cells do not undergo apoptosis after incubation with Resveratrol at concentration of 10 μM as determined by ApoAlert Annexin V Apoptosis kit^[2].
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling^[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm³; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm³; P<0.001) compare with the vehicle-treated animals (315±94 mm³). There is a good correlation between the tumor volume and the tumor mass^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

228.24

Appearance

Solid

Formula

C₁₄H₁₂O₃

CAS No.

501-36-0

SMILES

OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1

Structure Classification

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (438.14 mM; Need ultrasonic)

Ethanol : 50 mg/mL (219.07 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3814 mL	21.9068 mL	43.8135 mL
5 mM	0.8763 mL	4.3814 mL	8.7627 mL
10 mM	0.4381 mL	2.1907 mL	4.3814 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 16.67 mg/mL (73.04 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 50% PEG300 50% saline
Solubility: 12.5 mg/mL (54.77 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% saline
Solubility: 5 mg/mL (21.91 mM); Clear solution; Need ultrasonic
4.

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in saline)
Solubility: 5 mg/mL (21.91 mM); Clear solution; Need ultrasonic
5.

Add each solvent one by one: 10% EtOH 90% corn oil
Solubility: ≥ 5 mg/mL (21.91 mM); Clear solution
6.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
7.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
8.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
9.

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% saline
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
10.

Add each solvent one by one: 5% DMSO 95% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (281 KB) SDS (392 KB)

COA (245 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32. [Content Brief]

[2]. Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304. [Content Brief]

[3]. Lee MH, et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69(18):7449-58. [Content Brief]

[4]. Du LL, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014 Apr;36(2):613-23. [Content Brief]

[5]. Smutny T, et al. Resveratrol as an inhibitor of pregnane X receptor (PXR): another lesson in PXR antagonism. J Pharmacol Sci. 2014;126(2):177-8. [Content Brief]

[6]. Eun Nim Kim,et al. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging (Albany NY). 2018 Jan; 10(1): 83–99. [Content Brief]

[7]. Huige Li, et al. Resveratrol and Vascular Function. Int J Mol Sci. 2019 Apr 30;20(9):2155. [Content Brief]

Cell Assay ^[2]	To determine the effect of Resveratrol on cell growth, MCF-7 cells are plated in 6-well plates at 10⁵ cells per well in 2 mL of DME-F12 medium supplemented with 5% FBS in the presence or absence of increasing concentrations of Resveratrol. The cell number is measured every 2 days till day 6 with a hemocytometer after detaching the cells with trypsin-EDTA^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[3]	Mice^[3] Female BALB/c (nu/nu) mice, 6 weeks old, are used. PA-1 cells (1×10⁷ in 200 μL PBS) are injected s.c. on the right hind flank. Tumor volume (length×width×depth×0.52) is measured three times a week. After 10 days of implantation, two groups (n=10) are given Resveratrol (dissolved in 5% ethanol and 25% polyethyleneglycol 400 in distilled water) i.p. at a daily dose of 50 or 100 mg/kg body weight for consecutive 4 weeks, whereas the other group receive the vehicle only. Body weights are recorded everyday. Animals are given bromodeoxyuridine (BrdUrd; 10 mg/kg body weight, i.p.) 2 h before sacrifice. Xenograft tumors are weighed and frozen in liquid nitrogen or fixed in 10% formalin and embedded in paraffin. The BrdUrd-labeled cells in paraffin-embedded tissues are detected employing a monoclonal anti-BrdUrd antibody. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32. [Content Brief] [2]. Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304. [Content Brief] [3]. Lee MH, et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69(18):7449-58. [Content Brief] [4]. Du LL, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014 Apr;36(2):613-23. [Content Brief] [5]. Smutny T, et al. Resveratrol as an inhibitor of pregnane X receptor (PXR): another lesson in PXR antagonism. J Pharmacol Sci. 2014;126(2):177-8. [Content Brief] [6]. Eun Nim Kim,et al. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging (Albany NY). 2018 Jan; 10(1): 83–99. [Content Brief] [7]. Huige Li, et al. Resveratrol and Vascular Function. Int J Mol Sci. 2019 Apr 30;20(9):2155. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Resveratrol (Synonyms: trans-Resveratrol; SRT501)

Customer Review

Other Forms of Resveratrol:

56 Publications Citing Use of MCE Resveratrol

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Resveratrol (Synonyms: trans-Resveratrol; SRT501)

Customer Review

Other Forms of Resveratrol:

56 Publications Citing Use of MCE Resveratrol

Featured Recommendations

•Related Screening Libraries:

View All IKK Isoform Specific Products:

View All Sirtuin Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

Biological Activity

Protocol

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

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