Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

  • J Nat Prod. 2009 Oct;72(10):1895-8. doi: 10.1021/np900397f.
Ui Joung Youn  1 ,  Ye Seul Lee ,  Hana Jeong ,  Jun Lee ,  Joo-Won Nam ,  Yoo Jin Lee ,  Eun Sook Hwang ,  Je-Hyun Lee ,  Dongho Lee ,  Sam Sik Kang ,  Eun-Kyoung Seo
Affiliations
  • 1. The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
PMID: 19757853 DOI: 10.1021/np900397f
Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.