1. Metabolic Enzyme/Protease
  2. Tyrosinase
    Endogenous Metabolite
  3. 2-Ketoglutaric acid

2-Ketoglutaric acid (Synonyms: Alpha-Ketoglutaric acid)

Cat. No.: HY-W013636 Purity: >97.0%
Handling Instructions

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).

For research use only. We do not sell to patients.

2-Ketoglutaric acid Chemical Structure

2-Ketoglutaric acid Chemical Structure

CAS No. : 328-50-7

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500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2-Ketoglutaric acid:

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Description

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[1].

IC50 & Target

Human Endogenous Metabolite

 

Tyrosinase

15 mM (IC50)

In Vitro

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
2-Ketoglutaric acid acts as precursor for the synthesis of amino acids and nucleotides[2].

Molecular Weight

146.10

Formula

C₅H₆O₅

CAS No.

328-50-7

SMILES

OC(=O)CCC(=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (342.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8446 mL 34.2231 mL 68.4463 mL
5 mM 1.3689 mL 6.8446 mL 13.6893 mL
10 mM 0.6845 mL 3.4223 mL 6.8446 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >97.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Ketoglutaric acidAlpha-Ketoglutaric acidTyrosinaseEndogenous MetaboliteintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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2-Ketoglutaric acid
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