1. Metabolic Enzyme/Protease
  2. Tyrosinase
    Endogenous Metabolite
  3. 2-Ketoglutaric acid Sodium

2-Ketoglutaric acid Sodium (Synonyms: Alpha-Ketoglutaric acid Sodium)

Cat. No.: HY-W013636A
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2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).

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2-Ketoglutaric acid Sodium Chemical Structure

2-Ketoglutaric acid Sodium Chemical Structure

CAS No. : 22202-68-2

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Description

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Tyrosinase

15 mM (IC50)

In Vitro

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
2-Ketoglutaric acid Sodium acts as precursor for the synthesis of amino acids and nucleotides[2].

Molecular Weight

168.08

Formula

C₅H₅NaO₅

CAS No.

22202-68-2

SMILES

O=C(O[Na])C(CCC(O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

2-Ketoglutaric acidAlpha-Ketoglutaric acidTyrosinaseEndogenous MetaboliteintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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2-Ketoglutaric acid Sodium
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