2-Ketoglutaric acid Sodium
Based on 6 publication(s) in Google Scholar
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 22202-68-2
- Formula: C5H5NaO5
- Molecular Weight:168.08
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-F0003
NADPH tetrasodium salt
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HY-W009362
DL-Isocitric acid trisodium salt
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HY-W013636
2-Ketoglutaric acid
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HY-W013636R
2-Ketoglutaric acid (Standard)
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HY-W013636AG
2-Ketoglutaric acid Sodium (GMP)
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HY-W013636AR
2-Ketoglutaric acid Sodium (Standard)
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HY-D0889
Glycylglycine
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HY-D0889R
Glycylglycine (Standard)
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HY-D0841
Guanidine thiocyanate
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HY-D0841R
Guanidine thiocyanate (Standard)
Publications Citing Use of MedChemExpress (MCE) 2-Ketoglutaric acid Sodium
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Customer Validation & Images
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Cell Proliferation/Viability Assay
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Microbial Metabolite |
Tyrosinase 15 mM (IC50) |
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
2-Ketoglutaric acid Sodium acts as precursor for the synthesis of amino acids and nucleotides[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 22202-68-2
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Appearance Solid
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Molecular Weight 168.08
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Formula C5H5NaO5
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Color White to off-white
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SMILES
O=C(O[Na])C(CCC(O)=O)=O
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Synonyms
Alpha-Ketoglutaric acid Sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791
2-Ketoglutaric acid Sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112. [Abstract]
Cells were infected with PDCoV in Gln-containing medium, Gln-free medium, or Gln-free medium supplemented with oxoglutaric acid (αKG) (1 or 4 mM).
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Gut Microbes
2023 Jan-Dec;15(1):2186114. PMID: 36941257 -
Mol Biomed
Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13. [Abstract]2025 Dec 29;6(1):153. PMID: 41460571 -
PLoS Pathog
PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism. [Abstract]2024 Jun 21;20(6):e1012305. PMID: 38905309 -
Solvent & Solubility
H2O : 200 mg/mL (1189.91 mM; Need ultrasonic)
DMSO : 5.88 mg/mL (34.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]
[2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 5.9495 mL | 29.7477 mL | 59.4955 mL | 148.7387 mL |
| 5 mM | 1.1899 mL | 5.9495 mL | 11.8991 mL | 29.7477 mL | |
| 10 mM | 0.5950 mL | 2.9748 mL | 5.9495 mL | 14.8739 mL | |
| 15 mM | 0.3966 mL | 1.9832 mL | 3.9664 mL | 9.9159 mL | |
| 20 mM | 0.2975 mL | 1.4874 mL | 2.9748 mL | 7.4369 mL | |
| 25 mM | 0.2380 mL | 1.1899 mL | 2.3798 mL | 5.9495 mL | |
| 30 mM | 0.1983 mL | 0.9916 mL | 1.9832 mL | 4.9580 mL | |
| H2O | 40 mM | 0.1487 mL | 0.7437 mL | 1.4874 mL | 3.7185 mL |
| 50 mM | 0.1190 mL | 0.5950 mL | 1.1899 mL | 2.9748 mL | |
| 60 mM | 0.0992 mL | 0.4958 mL | 0.9916 mL | 2.4790 mL | |
| 80 mM | 0.0744 mL | 0.3718 mL | 0.7437 mL | 1.8592 mL | |
| 100 mM | 0.0595 mL | 0.2975 mL | 0.5950 mL | 1.4874 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Ketoglutaric acid Sodium Related Classifications
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