1. Metabolic Enzyme/Protease
  2. Tyrosinase Endogenous Metabolite
  3. Calcium 2-oxoglutarate

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).

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Calcium 2-oxoglutarate Chemical Structure

Calcium 2-oxoglutarate Chemical Structure

CAS No. : 71686-01-6

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Based on 2 publication(s) in Google Scholar

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Description

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

IC50 & Target[1]

Tyrosinase

15 mM (IC50)

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Calcium 2-oxoglutarate has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
Calcium 2-oxoglutarate acts as precursor for the synthesis of amino acids and nucleotides[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

184.16

Formula

C5H4CaO5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([O-])C(CCC([O-])=O)=O.[Ca+2]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 4.85 mg/mL (26.34 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4301 mL 27.1503 mL 54.3006 mL
5 mM 1.0860 mL 5.4301 mL 10.8601 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4301 mL 27.1503 mL 54.3006 mL 135.7515 mL
5 mM 1.0860 mL 5.4301 mL 10.8601 mL 27.1503 mL
10 mM 0.5430 mL 2.7150 mL 5.4301 mL 13.5752 mL
15 mM 0.3620 mL 1.8100 mL 3.6200 mL 9.0501 mL
20 mM 0.2715 mL 1.3575 mL 2.7150 mL 6.7876 mL
25 mM 0.2172 mL 1.0860 mL 2.1720 mL 5.4301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Calcium 2-oxoglutarate Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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