2. Metabolic Enzyme/Protease
  3. Tyrosinase Endogenous Metabolite
  4. Calcium 2-oxoglutarate

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).

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CAS No. : 71686-01-6

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Based on 6 publication(s) in Google Scholar

Other Forms of Calcium 2-oxoglutarate:

Calcium 2-oxoglutarate Related Antibodies

Top Publications Citing Use of Products

    Calcium 2-oxoglutarate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112.  [Abstract]

    Cells were infected with PDCoV in Gln-containing medium, Gln-free medium, or Gln-free medium supplemented with oxoglutaric acid (αKG) (1 or 4 mM).

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    Human Endogenous Metabolite Microbial Metabolite

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    Description

    Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

    IC50 & Target[1]

    Tyrosinase

    15 mM (IC50)

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Calcium 2-oxoglutarate has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
    Calcium 2-oxoglutarate acts as precursor for the synthesis of amino acids and nucleotides[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Calcium 2-oxoglutarate Related Antibodies
    Molecular Weight

    184.16

    Formula

    C5H4CaO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([O-])C(CCC([O-])=O)=O.[Ca+2]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    0.1 M HCl : 10 mg/mL (54.30 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4301 mL 27.1503 mL 54.3006 mL
    5 mM 1.0860 mL 5.4301 mL 10.8601 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    0.1 M HCl 1 mM 5.4301 mL 27.1503 mL 54.3006 mL 135.7515 mL
    5 mM 1.0860 mL 5.4301 mL 10.8601 mL 27.1503 mL
    10 mM 0.5430 mL 2.7150 mL 5.4301 mL 13.5752 mL
    15 mM 0.3620 mL 1.8100 mL 3.6200 mL 9.0501 mL
    20 mM 0.2715 mL 1.3575 mL 2.7150 mL 6.7876 mL
    25 mM 0.2172 mL 1.0860 mL 2.1720 mL 5.4301 mL
    30 mM 0.1810 mL 0.9050 mL 1.8100 mL 4.5251 mL
    40 mM 0.1358 mL 0.6788 mL 1.3575 mL 3.3938 mL
    50 mM 0.1086 mL 0.5430 mL 1.0860 mL 2.7150 mL
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    Calcium 2-oxoglutarate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Calcium 2-oxoglutarate71686-01-6TyrosinaseEndogenous MetaboliteintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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