Calcium 2-oxoglutarate
Based on 6 publication(s) in Google Scholar
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).
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- Reinheit: 98.0%
- CAS. Nr.: 71686-01-6
- Formel: C5H4CaO5
- Molecular Weight:184.16
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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- Verweise
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Publications Citing Use of MedChemExpress (MCE) Calcium 2-oxoglutarate
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Cell Proliferation/Viability Assay
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Tyrosinase 15 mM (IC50) |
Microbial Metabolite |
Human Endogenous Metabolite |
Calcium 2-oxoglutarate has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
Calcium 2-oxoglutarate acts as precursor for the synthesis of amino acids and nucleotides[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 71686-01-6
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Appearance Solid
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Molecular Weight 184.16
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Formel C5H4CaO5
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Color White to off-white
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SMILES
O=C([O-])C(CCC([O-])=O)=O.[Ca+2]
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791
Calcium 2-oxoglutarate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112. [Abstract]
Cells were infected with PDCoV in Gln-containing medium, Gln-free medium, or Gln-free medium supplemented with oxoglutaric acid (αKG) (1 or 4 mM).
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Gut Microbes
2023 Jan-Dec;15(1):2186114. PMID: 36941257 -
Mol Biomed
Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13. [Abstract]2025 Dec 29;6(1):153. PMID: 41460571 -
PLoS Pathog
PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism. [Abstract]2024 Jun 21;20(6):e1012305. PMID: 38905309 -
Lösungsmittel & Löslichkeit
0.1 M HCl : 10 mg/mL (54.30 mM; Need ultrasonic)
DMSO : 5.83 mg/mL (31.66 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]
[2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / 0.1 M HCl | 1 mM | 5.4301 mL | 27.1503 mL | 54.3006 mL | 135.7515 mL |
| 5 mM | 1.0860 mL | 5.4301 mL | 10.8601 mL | 27.1503 mL | |
| 10 mM | 0.5430 mL | 2.7150 mL | 5.4301 mL | 13.5752 mL | |
| 15 mM | 0.3620 mL | 1.8100 mL | 3.6200 mL | 9.0501 mL | |
| 20 mM | 0.2715 mL | 1.3575 mL | 2.7150 mL | 6.7876 mL | |
| 25 mM | 0.2172 mL | 1.0860 mL | 2.1720 mL | 5.4301 mL | |
| 30 mM | 0.1810 mL | 0.9050 mL | 1.8100 mL | 4.5251 mL | |
| 0.1 M HCl | 40 mM | 0.1358 mL | 0.6788 mL | 1.3575 mL | 3.3938 mL |
| 50 mM | 0.1086 mL | 0.5430 mL | 1.0860 mL | 2.7150 mL |
Calcium 2-oxoglutarate Related Classifications
HY-W013636B Related Classifications
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