2-Ketoglutaric acid potassium
Based on 6 publication(s) in Google Scholar
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC50 value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 997-43-3
- Formula: C5H6KO5
- Molecular Weight:185.20
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) 2-Ketoglutaric acid potassium
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Biological Activity
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1].
2-Ketoglutaric acid Sodium (GMP) acts as precursor for the synthesis of amino acids and nucleotides[2].
2-Ketoglutaric acid potassium (Compound 2-KT) (12.5-50 μM, 0-24 h) significantly suppresses the STI-induced reduction in the TEER values after 24 h and FITC-dextran permeability after 12 h as well as reducing inflammatory response in differentiated Caco-2 cells[3].
2-Ketoglutaric acid potassium (50 μM, 0-2 h) suppresses the STI-induced expression of MLXK and results in MLC phosphorylation in Caco-2 cells that are fully differentiated[3].
2-Ketoglutaric acid potassium (50 μM, 0-24 h) evidently suppresses STI-induced TAK1 phosphorylation in differentiated Caco-2 cells and the interaction between TAK1 and TRAF6 in differentiated Caco-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DSS-induced colon inflammation female C57BL/6 mice (8 w; 20 g) model[3]
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Dosage:2, 10 mg/kg/day
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Administration:Oral gavage (p.o.) for 14 d
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Result:Alleviated representative markers of IBD, including colon tissue damage, loss of crypts and destruction of the mucin layer.
Significantly suppressed DSS-induced IL-1β and TNF-α production in the mouse colon tissue.
Alleviated the DSS-induced ZO-1 and occludin delocalization from the cell membrane.
Chemical Information
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CAS No. 997-43-3
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Appearance Solid
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Molecular Weight 185.20
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Formula C5H6KO5
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Color White to off-white
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SMILES
O=C(C(CCC(O)=O)=O)O.[K]
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Synonyms
Alpha-Ketoglutaric acid potassium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791
2-Ketoglutaric acid potassium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112. [Abstract]
Cells were infected with PDCoV in Gln-containing medium, Gln-free medium, or Gln-free medium supplemented with oxoglutaric acid (αKG) (1 or 4 mM).
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Gut Microbes
2023 Jan-Dec;15(1):2186114. PMID: 36941257 -
Mol Biomed
Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by acting as a non-classical receptor of interleukin-13. [Abstract]2025 Dec 29;6(1):153. PMID: 41460571 -
PLoS Pathog
PoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism. [Abstract]2024 Jun 21;20(6):e1012305. PMID: 38905309 -
Solvent & Solubility
H2O : ≥ 100 mg/mL (539.96 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]
[2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]
[3]. Kim, S., et al., (2024). Hybrid nutraceutical of 2-ketoglutaric acid in improving inflammatory bowel disease: Role of prebiotics and TAK1 inhibitor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 171, 116126. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3996 mL | 26.9978 mL | 53.9957 mL | 134.9892 mL |
| 5 mM | 1.0799 mL | 5.3996 mL | 10.7991 mL | 26.9978 mL | |
| 10 mM | 0.5400 mL | 2.6998 mL | 5.3996 mL | 13.4989 mL | |
| 15 mM | 0.3600 mL | 1.7999 mL | 3.5997 mL | 8.9993 mL | |
| 20 mM | 0.2700 mL | 1.3499 mL | 2.6998 mL | 6.7495 mL | |
| 25 mM | 0.2160 mL | 1.0799 mL | 2.1598 mL | 5.3996 mL | |
| 30 mM | 0.1800 mL | 0.8999 mL | 1.7999 mL | 4.4996 mL | |
| 40 mM | 0.1350 mL | 0.6749 mL | 1.3499 mL | 3.3747 mL | |
| 50 mM | 0.1080 mL | 0.5400 mL | 1.0799 mL | 2.6998 mL | |
| 60 mM | 0.0900 mL | 0.4500 mL | 0.8999 mL | 2.2498 mL | |
| 80 mM | 0.0675 mL | 0.3375 mL | 0.6749 mL | 1.6874 mL | |
| 100 mM | 0.0540 mL | 0.2700 mL | 0.5400 mL | 1.3499 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Ketoglutaric acid potassium Related Classifications
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