2-Ketoglutaric acid-¹³C₅

Name: 2-Ketoglutaric acid- 13 C 5
Brand: MedChemExpress
SKU: HY-W013636S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W013636S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Ketoglutaric acid-¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

For research use only. We do not sell to patients.

2-Ketoglutaric acid-<sup>13</sup>C<sub>5</sub> Chemical Structure

2-Ketoglutaric acid-¹³C₅ Chemical Structure

CAS No. : 161096-83-9

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 175	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 282	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Ketoglutaric acid-¹³C₅:

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

151.06

Formula

¹³C₅H₆O₅

CAS No.

161096-83-9

Appearance

Solid

Color

White to off-white

SMILES

O[13C]([13CH2][13CH2][13C]([13C](O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1654.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6199 mL	33.0994 mL	66.1989 mL
5 mM	1.3240 mL	6.6199 mL	13.2398 mL
10 mM	0.6620 mL	3.3099 mL	6.6199 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB) HNMR (259 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]

[3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.6199 mL	33.0994 mL	66.1989 mL	165.4972 mL
	5 mM	1.3240 mL	6.6199 mL	13.2398 mL	33.0994 mL
	10 mM	0.6620 mL	3.3099 mL	6.6199 mL	16.5497 mL
	15 mM	0.4413 mL	2.2066 mL	4.4133 mL	11.0331 mL
	20 mM	0.3310 mL	1.6550 mL	3.3099 mL	8.2749 mL
	25 mM	0.2648 mL	1.3240 mL	2.6480 mL	6.6199 mL
	30 mM	0.2207 mL	1.1033 mL	2.2066 mL	5.5166 mL
	40 mM	0.1655 mL	0.8275 mL	1.6550 mL	4.1374 mL
	50 mM	0.1324 mL	0.6620 mL	1.3240 mL	3.3099 mL
	60 mM	0.1103 mL	0.5517 mL	1.1033 mL	2.7583 mL
	80 mM	0.0827 mL	0.4137 mL	0.8275 mL	2.0687 mL
	100 mM	0.0662 mL	0.3310 mL	0.6620 mL	1.6550 mL