NADPH tetrasodium salt
Based on 20 publication(s) in Google Scholar
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 2646-71-1
- Formula: C21H26N7Na4O17P3
- Molecular Weight:833.35
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) NADPH tetrasodium salt
More- Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
- Sci Adv. 2025 Dec 19;11(51):eady2104. [Abstract]
- Cell Rep Phys Sci. 2025 Mar 19.
- J Med Chem. 2025 Dec 25;68(24):26383-26404. [Abstract]
- J Agric Food Chem. 2024 Sep 11;72(36):20064-20076. [Abstract]
- Pharmaceutics. 2026 Jun 10;18(6):718. [Abstract]
- Chem Biol Interact. 2022 Dec 1:368:110222. [Abstract]
- Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
- Drug Des Devel Ther. 2020 Nov 30;14:5259-5273. [Abstract]
- Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
- J Mol Struct. 2026 Mar 10.
- Eur J Pharm Sci. 2021 Sep 1:164:105889. [Abstract]
- iScience. 2024 Aug 30;27(9):110834. [Abstract]
- Microbiol Spectr. 2023 Sep 21;11(5):e0267123. [Abstract]
- Vet Parasitol. 2026 May:344:110769. [Abstract]
- Xenobiotica. 2022 Feb;52(2):165-176. [Abstract]
- Res Sq. 2026 Jan 12.
- Chemrxiv. 2025 Aug 28.
- JID Innov. 2023 Nov 28;4(2):100251. [Abstract]
- Research Square Preprint. 2023 Jul 31.
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Human Endogenous Metabolite |
The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth[2].
NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress[3].
NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2646-71-1
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Appearance Solid
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Molecular Weight 833.35
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Formula C21H26N7Na4O17P3
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Color White to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O[Na])(O[Na])=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (20)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS-NADPH Dysregulation. [Abstract]2025 Sep 15:e07283. PMID: 40953299
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
A normal cellular state was recovered by adding TEMPO or NADPH (1mM, 24h), or SLC7A11 knockdown.
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
Western Blot analysis of RAC/WAVE pathway-related indicators in vitro skeletal muscle cells. Muscle cells treated with different condition NADPH(1mM, 24h).
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]
mtROS fluorescence staining of skeletal muscle cells in vitro. Muscle cells treated with different condition NADPH(1mM, 24h).
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Sci Adv
Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair. [Abstract]2025 Dec 19;11(51):eady2104. PMID: 41406205 -
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J Med Chem
Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance. [Abstract]2025 Dec 25;68(24):26383-26404. PMID: 41345987 -
J Agric Food Chem
2024 Sep 11;72(36):20064-20076. PMID: 39196852 -
Pharmaceutics
CYP3A-Mediated Metabolism of Zastaprazan in Humans and Associated Drug-Drug Interactions. [Abstract]2026 Jun 10;18(6):718. PMID: 42357334 -
Chem Biol Interact
Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases. [Abstract]2022 Dec 1:368:110222. PMID: 36244406 -
Mol Ther Oncol
AVL-armed oncolytic vaccinia virus promotes viral replication and boosts antitumor immunity via increasing ROS levels in pancreatic cancer. [Abstract]2024 Sep 17;32(4):200878. PMID: 39431173
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
Apoptosis proportion of oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM) or NADH. Data are presented as the mean ± SD (n=3).
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]
Western blotting detection of the expressions of caspase-3 and caspase-9 in oncoVV or oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM).
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Drug Des Devel Ther
Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach. [Abstract]2020 Nov 30;14:5259-5273. PMID: 33299299 -
Mol Plant Pathol
Negative Immune Regulator CAD7 Functions as a Small-Molecule Aldehyde Reductase and Increases Histamine Accumulation in Arabidopsis. [Abstract]2025 Dec;26(12):e70196. PMID: 41456913
NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]
Enzymatic activities of AtCAD7, AtCAD5, EcYahK, and EcYjgB toward (Z)‐3‐hexenal, acrolein, isovaleraldehyde, salicylaldehyde, and p‐coumaryl aldehyde. No Substrate was negative control. Assays were conducted under standardised conditions (30°C, pH 6.5, 100 μM substrate, 200 μM NADPH).
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Eur J Pharm Sci
Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors. [Abstract]2021 Sep 1:164:105889. PMID: 34044117 -
iScience
2024 Aug 30;27(9):110834. PMID: 39310768 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
Vet Parasitol
2026 May:344:110769. PMID: 41967379 -
Xenobiotica
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS. [Abstract]2022 Feb;52(2):165-176. PMID: 35345974 -
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JID Innov
ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201. [Abstract]2023 Nov 28;4(2):100251. PMID: 38299059 -
Solvent & Solubility
H2O : 125 mg/mL (150.00 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (120.00 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Tedeschi PM, et al. NAD+ Kinase as a Therapeutic Target in Cancer. Clin Cancer Res. 2016;22(21):5189-5195. [Content Brief]
[2]. Ng CY, F et al. Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration. Metab Eng. 2015;29:86-96. [Content Brief]
[3]. Ju HQ, Lin JF, et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020;5(1):231. Published 2020 Oct 7. [Content Brief]
[4]. Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171(2):273-285. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2000 mL | 5.9999 mL | 11.9998 mL | 29.9994 mL |
| 5 mM | 0.2400 mL | 1.2000 mL | 2.4000 mL | 5.9999 mL | |
| 10 mM | 0.1200 mL | 0.6000 mL | 1.2000 mL | 2.9999 mL | |
| 15 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 2.0000 mL | |
| 20 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.5000 mL | |
| 25 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.2000 mL | |
| 30 mM | 0.0400 mL | 0.2000 mL | 0.4000 mL | 1.0000 mL | |
| 40 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7500 mL | |
| 50 mM | 0.0240 mL | 0.1200 mL | 0.2400 mL | 0.6000 mL | |
| 60 mM | 0.0200 mL | 0.1000 mL | 0.2000 mL | 0.5000 mL | |
| 80 mM | 0.0150 mL | 0.0750 mL | 0.1500 mL | 0.3750 mL | |
| 100 mM | 0.0120 mL | 0.0600 mL | 0.1200 mL | 0.3000 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NADPH tetrasodium salt Related Classifications
HY-F0003 Related Classifications
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