NADPH tetracyclohexanamine

Name: NADPH tetracyclohexanamine
Brand: MedChemExpress
SKU: HY-F0003A
Rating: 5.0 (18 reviews)

Cat. No.: HY-F0003A Purity: 99.86%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

NADPH tetracyclohexanamine functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetracyclohexanamine is an endogenous inhibitor of ferroptosis. NADPH tetracyclohexanamine plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication.

For research use only. We do not sell to patients.

CAS No. : 100929-71-3

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 18 publication(s) in Google Scholar

Other Forms of NADPH tetracyclohexanamine:

NADPH In-stock
NADPH tetrasodium salt In-stock
NADPH tetracyclohexanamine (Standard) Get quote

18 Publications Citing Use of MCE NADPH tetracyclohexanamine

Cell Imaging/Staining

Bio/Physico-chemical Assay

Cell Proliferation/Viability Assay

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]; A normal cellular state was recovered by adding TEMPO or NADPH (1mM, 24h), or SLC7A11 knockdown.

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]; Western Blot analysis of RAC/WAVE pathway-related indicators in vitro skeletal muscle cells. Muscle cells treated with different condition NADPH(1mM, 24h).

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]; mtROS fluorescence staining of skeletal muscle cells in vitro. Muscle cells treated with different condition NADPH(1mM, 24h).

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]; Enzymatic activities of AtCAD7, AtCAD5, EcYahK, and EcYjgB toward (Z)‐3‐hexenal, acrolein, isovaleraldehyde, salicylaldehyde, and p‐coumaryl aldehyde. No Substrate was negative control. Assays were conducted under standardised conditions (30°C, pH 6.5, 100 μM substrate, 200 μM NADPH).

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]; Apoptosis proportion of oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM) or NADH. Data are presented as the mean ± SD (n=3).

: NADPH tetracyclohexanamine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]; Western blotting detection of the expressions of caspase-3 and caspase-9 in oncoVV or oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM).

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

The regeneration rate of NADPH tetracyclohexanamine is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth^[2].
NADPH tetracyclohexanamine homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetracyclohexanamine renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress^[3].
NADPH tetracyclohexanamine is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetracyclohexanamine levels are a biomarker of ferroptosis sensitivity across many cancer cell lines^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1142.12

Formula

C₄₅H₈₂N₁₁O₁₇P₃

CAS No.

100929-71-3

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(O)(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O)=O)=O.NC6CCCCC6.NC7CCCCC7.NC8CCCCC8.NC9CCCCC9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (87.56 mM)

DMSO : ≥ 84 mg/mL (73.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8756 mL	4.3778 mL	8.7556 mL
5 mM	0.1751 mL	0.8756 mL	1.7511 mL
10 mM	0.0876 mL	0.4378 mL	0.8756 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (251 KB) SDS (252 KB)

COA (256 KB) HNMR (352 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	0.8756 mL	4.3778 mL	8.7556 mL	21.8891 mL
	5 mM	0.1751 mL	0.8756 mL	1.7511 mL	4.3778 mL
	10 mM	0.0876 mL	0.4378 mL	0.8756 mL	2.1889 mL
	15 mM	0.0584 mL	0.2919 mL	0.5837 mL	1.4593 mL
	20 mM	0.0438 mL	0.2189 mL	0.4378 mL	1.0945 mL
	25 mM	0.0350 mL	0.1751 mL	0.3502 mL	0.8756 mL
	30 mM	0.0292 mL	0.1459 mL	0.2919 mL	0.7296 mL
	40 mM	0.0219 mL	0.1094 mL	0.2189 mL	0.5472 mL
	50 mM	0.0175 mL	0.0876 mL	0.1751 mL	0.4378 mL
	60 mM	0.0146 mL	0.0730 mL	0.1459 mL	0.3648 mL
H₂O	80 mM	0.0109 mL	0.0547 mL	0.1094 mL	0.2736 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.