2. Epigenetics
  3. Histone Acetyltransferase
  4. NSC 694621

NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 µM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells.

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NSC 694621 Chemical Structure

NSC 694621 Chemical Structure

CAS No. : 104857-29-6

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Based on 1 publication(s) in Google Scholar

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Description

NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 µM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells[1].

IC50 & Target

IC50: 5.71 µM (PCAF/H31-21)[1].
In Vitro

NSC 694621 (25 µM; 72 h) exhibits antiproliferative effect to SK-N-SH and HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 694621 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SK-N-SH, HCT116 cells
Concentration: 25 µM
Incubation Time: 72 h
Result: Showed antiproliferative effect to SK-N-SH and HCT116 cells with GI50 of 19.2 µM and growth inhibition of 29%, respectively.
Molecular Weight

258.30

Formula

C13H10N2O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CN=C2SN1C3=CC=C(C=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (12.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8715 mL 19.3573 mL 38.7147 mL
5 mM 0.7743 mL 3.8715 mL 7.7429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8715 mL 19.3573 mL 38.7147 mL 96.7867 mL
5 mM 0.7743 mL 3.8715 mL 7.7429 mL 19.3573 mL
10 mM 0.3871 mL 1.9357 mL 3.8715 mL 9.6787 mL
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NSC 694621 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 694621104857-29-6NSC694621NSC-694621Histone AcetyltransferaseHATsHATPCAFpyridoisothiazolonesHAT inhibitorcancerSK-N-SHHCT116Inhibitorinhibitorinhibit

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