2. Anti-infection
  3. Parasite
  4. JC-229

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT).

For research use only. We do not sell to patients.

JC-229 Chemical Structure

JC-229 Chemical Structure

CAS No. : 3026716-22-0

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5 mg USD 55 In-stock
10 mg USD 85 In-stock
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Description

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT)[1].

Molecular Weight

504.21

Formula

C20H14Cl4N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(Cl)C(Cl)=C1)C2=CC=C(C)C(S(=O)(NC3=CC=C(Cl)C(Cl)=C3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (79.33 mM; ultrasonic and adjust pH to 9 with 1M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9833 mL 9.9165 mL 19.8330 mL
5 mM 0.3967 mL 1.9833 mL 3.9666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9833 mL 9.9165 mL 19.8330 mL 49.5825 mL
5 mM 0.3967 mL 1.9833 mL 3.9666 mL 9.9165 mL
10 mM 0.1983 mL 0.9917 mL 1.9833 mL 4.9583 mL
15 mM 0.1322 mL 0.6611 mL 1.3222 mL 3.3055 mL
20 mM 0.0992 mL 0.4958 mL 0.9917 mL 2.4791 mL
25 mM 0.0793 mL 0.3967 mL 0.7933 mL 1.9833 mL
30 mM 0.0661 mL 0.3306 mL 0.6611 mL 1.6528 mL
40 mM 0.0496 mL 0.2479 mL 0.4958 mL 1.2396 mL
50 mM 0.0397 mL 0.1983 mL 0.3967 mL 0.9917 mL
60 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.8264 mL
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JC-229 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JC-2293026716-22-0JC229JC 229ParasiteTbRPA1Trypanosoma bruceiHuman African Trypanosomiasis (HAT)Inhibitorinhibitorinhibit

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