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KAT8-IN-1 

Cat. No.: HY-W015239 Purity: 98.73%
COA Handling Instructions

KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases.

For research use only. We do not sell to patients.

KAT8-IN-1 Chemical Structure

KAT8-IN-1 Chemical Structure

CAS No. : 605-62-9

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Based on 1 publication(s) in Google Scholar

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Description

KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].

IC50 & Target

IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B)[1]
In Vitro

KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

189.17

Appearance

Solid

Formula

C10H7NO3
CAS No.
SMILES

OC1=C2C=CC=CC2=C([N+]([O-])=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (528.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2863 mL 26.4313 mL 52.8625 mL
5 mM 1.0573 mL 5.2863 mL 10.5725 mL
10 mM 0.5286 mL 2.6431 mL 5.2863 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (13.22 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.73%

COA (253 KB) HNMR (124 KB) RP-HPLC (95 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

KAT8-IN-1605-62-9Othersfragment screeninghistone acetylationenzyme kineticsacetylated enzymefree enzymeInhibitorinhibitorinhibit

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