1. Anti-infection
  2. Parasite

Fexinidazole (Synonyms: HOE 239)

Cat. No.: HY-13801 Purity: 99.87%
Handling Instructions

Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei.

For research use only. We do not sell to patients.

Fexinidazole Chemical Structure

Fexinidazole Chemical Structure

CAS No. : 59729-37-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 204 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei. Target: Antiparasitic in vivo: Fexinidazole shows dose-related efficacy in the T. b. rhodesiense (STIB900) acute mouse model at intraperitoneal (i.p.) doses of 20 to 50 mg/kg/day and oral (per os [p.o.]) doses of 25 to 100 mg/kg/day given on four consecutive days, with 100 mg/kg/day p.o. being 100% curative. Fexinidazole is shown to be effective in the GVR35 mouse model, which mimics the advanced and fatal stage of the disease, when parasites have disseminated into the brain. [1]

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5803 mL 17.9013 mL 35.8025 mL
5 mM 0.7161 mL 3.5803 mL 7.1605 mL
10 mM 0.3580 mL 1.7901 mL 3.5803 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

279.31

Formula

C₁₂H₁₃N₃O₃S

CAS No.

59729-37-2

SMILES

O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.87%

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Product Name:
Fexinidazole
Cat. No.:
HY-13801
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Fexinidazole

Cat. No.: HY-13801