1. Anti-infection
  2. Parasite
  3. Fexinidazole

Fexinidazole (Synonyms: HOE 239)

Cat. No.: HY-13801 Purity: 99.92%
Handling Instructions

Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal drug. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei.

For research use only. We do not sell to patients.

Fexinidazole Chemical Structure

Fexinidazole Chemical Structure

CAS No. : 59729-37-2

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal drug. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei[1].

In Vitro

Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesiense[1]
Dosage: 20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO)
Administration: IP or PO; daily; four consecutive days
Result: Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.
Clinical Trial
Molecular Weight

279.31

Formula

C₁₂H₁₃N₃O₃S

CAS No.

59729-37-2

SMILES

O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (179.01 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5803 mL 17.9013 mL 35.8025 mL
5 mM 0.7161 mL 3.5803 mL 7.1605 mL
10 mM 0.3580 mL 1.7901 mL 3.5803 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (8.95 mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

FexinidazoleHOE 239HOE239HOE-239ParasiteorallynitroimidazoleantitrypanosomalT.bruceisleepingsicknessHATInhibitorinhibitorinhibit

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Product Name:
Fexinidazole
Cat. No.:
HY-13801
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