1. Epigenetics
    Apoptosis
  2. Histone Acetyltransferase
    Epigenetic Reader Domain
    Apoptosis
  3. MG 149

MG 149 (Synonyms: Tip60 HAT inhibitor)

Cat. No.: HY-15887 Purity: 99.07%
Handling Instructions

MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).

For research use only. We do not sell to patients.

MG 149 Chemical Structure

MG 149 Chemical Structure

CAS No. : 1243583-85-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 864 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM)[1].

IC50 & Target

IC50: 74/47 μM (Tip60/MOF)[1]

In Vitro

MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05)[1].

Molecular Weight

340.46

Formula

C₂₂H₂₈O₃

CAS No.

1243583-85-8

SMILES

O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (293.72 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9372 mL 14.6860 mL 29.3720 mL
5 mM 0.5874 mL 2.9372 mL 5.8744 mL
10 mM 0.2937 mL 1.4686 mL 2.9372 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (8.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MG 149Tip60 HAT inhibitorMG149MG-149Histone AcetyltransferaseEpigenetic Reader DomainApoptosisHATsHATInhibitorinhibitorinhibit

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Product name:
MG 149
Cat. No.:
HY-15887
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