1. Epigenetics
  2. Epigenetic Reader Domain
    Histone Acetyltransferase

SGC-CBP30 

Cat. No.: HY-15826 Purity: 99.74%
Handling Instructions

SGC-CBP30 is a potent CREBBP/EP300 bromodomain inhibitor with IC50 of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively.

For research use only. We do not sell to patients.

SGC-CBP30 Chemical Structure

SGC-CBP30 Chemical Structure

CAS No. : 1613695-14-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 181 In-stock
Estimated Time of Arrival: December 31
5 mg USD 162 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 643 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1158 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SGC-CBP30 is a potent CREBBP/EP300 bromodomain inhibitor with IC50 of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively. IC50 Value: 21-69 nM(for CREBBP); 38 nM(for EP300) Target: Others in vivo: SGC-CBP30 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.021-0.069 uM for CBP and ~0.038 uM for p300). It has 40-fold selectivity for CBP over BRD4. It accelerated FRAP recovery at 1 uM. in vivo: N/A

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (60.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9645 mL 9.8224 mL 19.6448 mL
5 mM 0.3929 mL 1.9645 mL 3.9290 mL
10 mM 0.1964 mL 0.9822 mL 1.9645 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

509.04

Formula

C₂₈H₃₃ClN₄O₃

CAS No.

1613695-14-9

SMILES

C[[email protected]](N1CCOCC1)CN2C(CCC3=CC=C(OC)C(Cl)=C3)=NC4=CC(C5=C(C)ON=C5C)=CC=C42

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.74%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SGC-CBP30
Cat. No.:
HY-15826
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SGC-CBP30

Cat. No.: HY-15826