1. Signaling Pathways
  2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD3 Isoform

BRD3

 

BRD3 Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-112090
    ABBV-744
    Inhibitor 99.97%
    ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT.
  • HY-100972
    ARV-771
    Inhibitor 99.02%
    ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
  • HY-136570
    GSK778
    Inhibitor 99.25%
    GSK778 (iBET-BD1) is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
  • HY-136571
    GSK046
    Inhibitor 98.15%
    GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
  • HY-101519
    BETd-260
    Inhibitor 99.01%
    BETd-260 (ZBC 260) is a PROTAC connected by ligands for Cereblon and BET, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
  • HY-152213
    BET-IN-13
    Inhibitor
    BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM.
  • HY-112429
    HJB97
    Inhibitor 98.24%
    HJB97 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively.
  • HY-114416
    GS-626510
    Inhibitor 99.86%
    GS-626510 is a potent, and orally active BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively.
  • HY-141438
    SIM1
    Inhibitor 99.72%
    SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM).
  • HY-130622
    LT052
    Inhibitor 98.49%
    LT052 is a highly selective BET BD1 inhibitor with an IC50 of 87.7 nM.
  • HY-120000
    MS402
    Inhibitor 98.98%
    MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively.
  • HY-112610
    CF53
    Inhibitor 99.78%
    CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1.
  • HY-145264
    OARV-771
    Inhibitor
    OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability.
  • HY-131061
    BET bromodomain inhibitor 1
    Inhibitor 99.91%
    BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4.
  • HY-114504
    RVX-297
    Inhibitor
    RVX-297 is a potent, orally active BET bromodomain inhibitor with selectivity for BD2.
  • HY-126325
    BY27
    Inhibitor
    BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT.
  • HY-138563
    GSK973
    Inhibitor
    GSK973 is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family, with a pIC50 of 7.8 and a pKd of 8.7 for BRD4 BD2.
  • HY-110215
    XD14
    Inhibitor
    XD14 is a potent BET inhibitor with antitumor effect.