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  3. MS402

MS402 

Cat. No.: HY-120000 Purity: 98.98%
Handling Instructions

MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.

For research use only. We do not sell to patients.

MS402 Chemical Structure

MS402 Chemical Structure

CAS No. : 1672684-68-2

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5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 125 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MS402

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice[1].

IC50 & Target[1]

BRD4-BD1

77 nM (Ki)

BRD2-BD1

83 nM (Ki)

BRD3-BD1

110 nM (Ki)

BRD3-BD2

200 nM (Ki)

BRD2-BD2

240 nM (Ki)

BRD4-BD2

718 nM (Ki)

In Vivo

Reconstitution with naïve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, Rag1-/- mice with T-cell transfer-induced colitis model[1]
Dosage: 10 mg/kg
Administration: Intraperitoneally twice a week for 3 weeks
Result: Showed much less weight loss.
Molecular Weight

370.83

Formula

C₂₀H₁₉ClN₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (269.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6967 mL 13.4833 mL 26.9665 mL
5 mM 0.5393 mL 2.6967 mL 5.3933 mL
10 mM 0.2697 mL 1.3483 mL 2.6967 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (6.74 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
MS402
Cat. No.:
HY-120000
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