BRPF2

BRPF2 (also known as BRD1) is a bromodomain- and PHD finger-containing chromatin regulator that functions as a scaffold component of histone acetyltransferase complexes involved in epigenetic gene regulation^[1]. Mechanistically, BRPF2 forms the HBO1-BRPF2 complex, which is responsible for global acetylation of histone H3 lysine 14 (H3K14ac), a chromatin modification associated with transcriptional regulation and chromatin accessibility^[1]. Through control of H3K14 acetylation, BRPF2 participates in chromatin-dependent transcriptional programs that support cellular differentiation processes^[1][2]. In experimental models, genetic disruption of the HBO1-BRPF2 complex markedly impairs fetal liver erythropoiesis, establishing a functional link between BRPF2-mediated histone acetylation and hematopoietic development^[1]. BRPF2 is also associated with transcriptional activation of genes involved in erythrocyte differentiation, further supporting its role in lineage-specific gene regulation^[2]. Compared with related BRPF family members, BRPF2 is distinguished by its documented requirement within the HBO1-BRPF2 complex for global H3K14 acetylation during erythropoietic development, whereas alternative BRPF-containing complexes have been linked to distinct biological contexts and acetyltransferase activities^[1][3]. At the molecular level, the first PHD finger of BRPF2 recognizes unmodified histone H3, providing mechanistic insight into how BRPF2 contributes to chromatin targeting and regulation of MOZ/MORF-associated histone acetyltransferase activity^[4].