BRPF1B/TRIM24-IN-1
BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM.
For research use only. We do not sell to patients.
- CAS No.: 1242907-48-7
- Formula: C24H25N3O7S
- Molecular Weight:499.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRPF1 0.34 μM (IC50) |
BRPF2 1.75 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MM1.S | GI50 |
>10 μM
Compound: 34
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Cytotoxicity against human MM1S cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human MM1S cells after 72 hrs by CellTiter-Glo assay
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[PMID: 25974391] |
BRPF1B/TRIM24-IN-1 (compound 34) shows no significant cytotoxicity in breast cancer cell line MCF-7. BRPF1B/TRIM24-IN-1 has modest cytotoxicity on a panel of cancer cell lines (MM1S, RCH-ACH, JJN3, RKO) (GI50 > 10 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1242907-48-7
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Molecular Weight 499.54
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Formula C24H25N3O7S
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SMILES
O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRPF1B/TRIM24-IN-1 Related Classifications
HY-122626 Related Classifications
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