1. Signaling Pathways
  2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 Isoform

BRD4

 

BRD4 Related Products (84):

Cat. No. Product Name Effect Purity
  • HY-100972
    ARV-771
    Inhibitor 99.02%
    ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
  • HY-112090
    ABBV-744
    Inhibitor 99.97%
    ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT.
  • HY-101838
    dBET1
    Inhibitor 99.24%
    dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM.
  • HY-136570
    GSK778
    Inhibitor 99.25%
    GSK778 (iBET-BD1) is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
  • HY-14443
    XMD8-92
    Inhibitor 99.93%
    XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively.
  • HY-143299
    BRD4-BD1-IN-1
    Inhibitor
    BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor with an IC50 of 38.20 μM.
  • HY-152213
    BET-IN-13
    Inhibitor
    BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM.
  • HY-150613
    PARP1/BRD4-IN-2
    Inhibitor
    PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively.
  • HY-136571
    GSK046
    Inhibitor 98.15%
    GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
  • HY-122826
    ZXH-3-26
    Inhibitor 98.61%
    ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM.
  • HY-100482
    CPI-637
    Inhibitor 99.94%
    CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.
  • HY-101519
    BETd-260
    Inhibitor 99.01%
    BETd-260 (ZBC 260) is a PROTAC connected by ligands for Cereblon and BET, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
  • HY-123844
    dBET57
    Inhibitor 99.66%
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology.
  • HY-114305
    A1874
    Inhibitor 99.28%
    A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells).
  • HY-129937A
    GNE-987
    Inhibitor 99.91%
    GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4.
  • HY-19999A
    PF-CBP1 hydrochloride
    Inhibitor 99.99%
    PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD).
  • HY-125232
    MS645
    ≥98.0%
    MS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2.
  • HY-103632
    PROTAC BRD9 Degrader-1
    Inhibitor 98.30%
    PROTAC BRD9 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD9 (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology.
  • HY-129917
    KB02-JQ1
    Inhibitor 98.29%
    KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3.
  • HY-112376
    MZP-54
    Inhibitor 98.16%
    MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.