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  3. ZXH-3-26

ZXH-3-26 

Cat. No.: HY-122826
Handling Instructions

ZXH-3-26 is a selective BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM.

For research use only. We do not sell to patients.

ZXH-3-26 Chemical Structure

ZXH-3-26 Chemical Structure

CAS No. : 2243076-67-5

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Description

ZXH-3-26 is a selective BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM[1].

IC50 & Target[1]

BRD4

5 nM (DC50, 5 hours of treatment)

In Vitro

ZXH-3-26 represents the first small molecule to allow pharmacologic targeting of BRD4 without significant inhibition or degradation of BRD2/3[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (254.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2734 mL 6.3672 mL 12.7345 mL
5 mM 0.2547 mL 1.2734 mL 2.5469 mL
10 mM 0.1273 mL 0.6367 mL 1.2734 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (6.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

785.27

Formula

C₃₈H₃₇ClN₈O₇S

CAS No.

2243076-67-5

SMILES

O=C(OC)C[[email protected]]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
ZXH-3-26
Cat. No.:
HY-122826
Quantity:

ZXH-3-26

Cat. No.: HY-122826