1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. PROTAC BET-binding moiety 2

PROTAC BET-binding moiety 2 

Cat. No.: HY-43723 Purity: 98.85%
Handling Instructions

PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain.

For research use only. We do not sell to patients.

PROTAC BET-binding moiety 2 Chemical Structure

PROTAC BET-binding moiety 2 Chemical Structure

CAS No. : 916493-82-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain[1].

Molecular Weight

444.89

Formula

C₂₀H₁₇ClN₄O₄S

CAS No.

916493-82-8

SMILES

CC1=C(C(O)=O)SC2=C1C(C3=CC=C(Cl)C=C3)=N[[email protected]@H](CC(OC)=O)C4=NN=C(C)N24

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 42.86 mg/mL (96.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2477 mL 11.2387 mL 22.4775 mL
5 mM 0.4495 mL 2.2477 mL 4.4955 mL
10 mM 0.2248 mL 1.1239 mL 2.2477 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PROTAC BET-binding moiety 2
Cat. No.:
HY-43723
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