1. Signaling Pathways
  2. PROTAC
  3. PROTACs
  4. Cereblon Isoform

Cereblon

 

Cereblon Related Products (52):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101838
    dBET1 1799711-21-9 99.24%
    dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM.
    dBET1
  • HY-129602
    SD-36 2429877-44-9 99.46%
    SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members.
    SD-36
  • HY-111556
    BSJ-03-123 2361493-16-3 98.13%
    BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
    BSJ-03-123
  • HY-129523
    PROTAC K-Ras Degrader-1 2378258-52-5 98.05%
    PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells.
    PROTAC K-Ras Degrader-1
  • HY-139039
    BSJ-4-116 2519823-34-6 99.62%
    BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK.
    BSJ-4-116
  • HY-133120A
    INY-03-041 trihydrochloride
    INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib (HY-15186) conjugated to INY-03-041 trihydrochloride
  • HY-122653A
    CCT367766 formic 98.02%
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration.
    CCT367766 formic
  • HY-151886
    NU223612 2759420-43-2
    NU223612 is a potent PROTAC ( NU223612
  • HY-134582
    dCBP-1 2484739-25-3 99.44%
    dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand.
    dCBP-1
  • HY-112155
    MS4078 2229036-62-6 99.63%
    MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
    MS4078
  • HY-130665
    TL12-186 2250025-88-6 ≥99.0%
    TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader.
    TL12-186
  • HY-122826
    ZXH-3-26 2243076-67-5 98.61%
    ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM.
    ZXH-3-26
  • HY-114421
    FKBP12 PROTAC dTAG-13 2064175-41-1 99.52%
    FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest.
    FKBP12 PROTAC dTAG-13
  • HY-130709
    PROTAC CDK2/9 Degrader-1 2408641-24-5 99.85%
    PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM).
    PROTAC CDK2/9 Degrader-1
  • HY-133137
    SJF620 2376187-16-3 99.27%
    SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM.
    SJF620
  • HY-129966
    PROTAC IRAK4 degrader-1 2360533-90-8 99.72%
    PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.
    PROTAC IRAK4 degrader-1
  • HY-133557
    XZ739 2365172-19-4 99.06%
    XZ739, a Cereblon-dependent PROTAC BCL-XL (Bcl-2 family member) degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment.
    XZ739
  • HY-125835
    CP-10 2366268-80-4 98.22%
    CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM).
    CP-10
  • HY-111870
    PROTAC RIPK degrader-6 2089205-64-9 99.32%
    PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.
    PROTAC RIPK degrader-6
  • HY-141512
    JB170 2705844-82-0 98.40%
    JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide.
    JB170