1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTACs
    CDK
  3. BSJ-03-123

BSJ-03-123 

Cat. No.: HY-111556 Purity: 99.45%
Handling Instructions

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

For research use only. We do not sell to patients.

BSJ-03-123 Chemical Structure

BSJ-03-123 Chemical Structure

CAS No. : 2361493-16-3

Size Price Stock Quantity
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BSJ-03-123

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

IC50 & Target

CDK6

 

Cereblon

 

In Vitro

BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

937.01

Formula

C47H56N10O11

CAS No.
SMILES

O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (106.72 mM; ultrasonic and adjust pH to 3 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0672 mL 5.3361 mL 10.6722 mL
5 mM 0.2134 mL 1.0672 mL 2.1344 mL
10 mM 0.1067 mL 0.5336 mL 1.0672 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.45%

References
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Product Name:
BSJ-03-123
Cat. No.:
HY-111556
Quantity:
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