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Cat. No.: HY-111556

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BSJ-03-123

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
(Pink: CDK ligand (HY-50767); Blue: Cereblon ligand (HY-103597); Black: linker (HY-W046471)).

For research use only. We do not sell to patients.

Purity: 99.19%
CAS No.: 2361493-16-3
Formula: C₄₇H₅₆N₁₀O₁₁
Molecular Weight:937.01

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

BSJ-03-123 Chemical Structure

CAS No.: 2361493-16-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader. (Pink: CDK ligand (HY-50767); Blue: Cereblon ligand (HY-103597); Black: linker (HY-W046471)).

IC₅₀ & Target

CDK6

Cereblon

All PROTACs Isoforms :

All CDK Isoforms :

In Vitro

BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2361493-16-3
Appearance Solid
Molecular Weight 937.01
Formula C₄₇H₅₆N₁₀O₁₁
Color White to yellow
SMILES

O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

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Cancer Cell

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. [Abstract]

2024 Aug 27:S1535-6108(24)00305-2. PMID: 39232581
J Adv Res

Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis. [Abstract]

2024 Aug 5:S2090-1232(24)00313-8. PMID: 39107200
Cell Rep

Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance. [Abstract]

2023 Mar 30;42(4):112314. PMID: 37000627
Cancers (Basel)

CDK6 Degradation Is Counteracted by p16INK4A and p18INK4C in AML. [Abstract]

2022 Mar 18;14(6):1554. PMID: 35326705
Structure

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. [Abstract]

2024 Dec 5;32(12):2352-2363.e8. PMID: 39389062

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (26.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0672 mL

5.3361 mL

10.6722 mL

5 mM

0.2134 mL

1.0672 mL

2.1344 mL

10 mM

0.1067 mL

0.5336 mL

1.0672 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0672 mL	5.3361 mL	10.6722 mL	26.6806 mL
	5 mM	0.2134 mL	1.0672 mL	2.1344 mL	5.3361 mL
	10 mM	0.1067 mL	0.5336 mL	1.0672 mL	2.6681 mL
	15 mM	0.0711 mL	0.3557 mL	0.7115 mL	1.7787 mL
	20 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3340 mL
	25 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

MedChemExpress Validation
The above results were obtained using AlphaLISA™ SureFire® Ultra™ assays.
1/16

MedChemExpress Validation
The above results were obtained using AlphaLISA™ SureFire® Ultra™ assays.
1/16

MedChemExpress Validation
The above results were obtained using AlphaLISA™ SureFire® Ultra™ assays.

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BSJ-03-123

PROTAC Library

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BSJ-03-123

All PROTACs Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BSJ-03-123

PROTAC Library

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BSJ-03-123

All PROTACs Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BSJ-03-123 Related Classifications

HY-111556 Related Classifications