1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    PROTAC
  3. BSJ-03-123

BSJ-03-123 

Cat. No.: HY-111556
Handling Instructions

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader.

For research use only. We do not sell to patients.

BSJ-03-123 Chemical Structure

BSJ-03-123 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 361 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader.

IC50 & Target

CDK6, PROTAC[1]

In Vitro

BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis[1].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (133.40 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0672 mL 5.3361 mL 10.6722 mL
5 mM 0.2134 mL 1.0672 mL 2.1344 mL
10 mM 0.1067 mL 0.5336 mL 1.0672 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

937.01

Formula

C₄₇H₅₆N₁₀O₁₁

SMILES

O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3

Shipping

Room temperature in continental US; may vary elsewhere

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
BSJ-03-123
Cat. No.:
HY-111556
Quantity:

BSJ-03-123

Cat. No.: HY-111556