1. Signaling Pathways
  2. PROTAC
  3. PROTACs
  4. von Hippel-Lindau (VHL) Isoform

von Hippel-Lindau (VHL)

 

von Hippel-Lindau (VHL) Related Products (32):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-137516
    LC-2 2502156-03-6
    LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM.
    LC-2
  • HY-130492
    ARCC-4 1973403-00-7 99.54%
    ARCC-4 is a low-nanomolar Androgen Receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM.
    ARCC-4
  • HY-111866
    PROTAC RIPK degrader-2 1801547-16-9 99.05%
    PROTAC RIPK degrader-2 is a nonpeptidic PROTAC based on von Hippel-Lindau ligand which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
    PROTAC RIPK degrader-2
  • HY-129937A
    GNE-987 2417371-71-0 98.90%
    GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4.
    GNE-987
  • HY-133020
    ARD-266 99.67%
    ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor (AR) PROTAC degrader.
    ARD-266
  • HY-141877B
    MS4322 (isomer) 2601727-80-2 99.22%
    MS4322 (YS43-22) isomer is an isomer of MS4322.
    MS4322 (isomer)
  • HY-151623
    ACBI2
    ACBI2 is a highly potent and orally active VHL PROTAC (EC50: 7 nM), which selectively degrades SMARCA2 with a DC50 value of 1 nM in RKO cells.
    ACBI2
  • HY-111593
    Homo-PROTAC pVHL30 degrader 1 2244684-49-7 99.83%
    Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consists of two ligands of von Hippel-Lindau.
    Homo-PROTAC pVHL30 degrader 1
  • HY-112376
    MZP-54 2010159-47-2 98.16%
    MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.
    MZP-54
  • HY-128756
    SIAIS178 2376047-73-1 99.48%
    SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM.
    SIAIS178
  • HY-128845
    PROTAC CRBN Degrader-1 2358775-70-7 99.34%
    PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
    PROTAC CRBN Degrader-1
  • HY-141796
    MS67 2407452-77-9 98.73%
    MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM.
    MS67
  • HY-130615
    PROTAC EED degrader-2 2639882-69-0 98.64%
    PROTAC EED degrader-2 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.27.
    PROTAC EED degrader-2
  • HY-139185
    PROTAC ERRα Degrader-3 2306388-65-6 98.82%
    PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand.
    PROTAC ERRα Degrader-3
  • HY-130614
    PROTAC EED degrader-1 2639882-72-5 99.56%
    PROTAC EED degrader-1 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.02.
    PROTAC EED degrader-1
  • HY-135345
    PROTAC FKBP Degrader-3 2079056-43-0 98.73%
    PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group.
    PROTAC FKBP Degrader-3
  • HY-132857A
    ZXH-4-130 TFA 2711006-67-4 99.53%
    ZXH-4-130 TFA is a highly potent and selective degrader of CRBN.
    ZXH-4-130 TFA
  • HY-141877
    MS4322 2375432-47-4
    MS4322 (YS43-22) is a first-in-class PRMT5 degrader and a valuable chemical tool (PROTAC) for exploring the PRMT5 functions in health and disease.
    MS4322
  • HY-135309
    PROTAC ER Degrader-4 2361114-15-8 98.05%
    PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM.
    PROTAC ER Degrader-4
  • HY-114404
    SJFα 2254609-27-1 99.61%
    SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand.
    SJFα