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  4. Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1 

Cat. No.: HY-111593 Purity: 99.83%
COA Handling Instructions

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consists of two ligands of von Hippel-Lindau.

For research use only. We do not sell to patients.

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

CAS No. : 2244684-49-7

Size Price Stock Quantity
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 640 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

IC50 & Target

VHL

 

In Vitro

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1179.45

Appearance

Solid

Formula

C58H82N8O14S2
CAS No.
SMILES

CC1=C(C2=CC=C(CNC([[email protected]@H]3C[[email protected]@]([H])(O)CN3C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N4[[email protected]](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[[email protected]@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (127.18 mM)

H2O : 25 mg/mL (21.20 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8479 mL 4.2393 mL 8.4785 mL
5 mM 0.1696 mL 0.8479 mL 1.6957 mL
10 mM 0.0848 mL 0.4239 mL 0.8479 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Homo-PROTAC pVHL30 degrader 12244684-49-7PROTACsInhibitorinhibitorinhibit

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