1. PROTAC
  2. Ligand for E3 Ligase
    PROTAC
  3. Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1 

Cat. No.: HY-111593 Purity: 99.56%
Handling Instructions

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.

For research use only. We do not sell to patients.

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

CAS No. : 2244684-49-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 973 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].

IC50 & Target

pVHL30[1]
PROTAC[1]

In Vitro

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

Molecular Weight

1179.45

Formula

C₅₈H₈₂N₈O₁₄S₂

CAS No.

2244684-49-7

SMILES

CC1=C(C2=CC=C(CNC([[email protected]@H]3C[[email protected]@]([H])(O)CN3C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N4[[email protected]](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[[email protected]@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (127.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8479 mL 4.2393 mL 8.4785 mL
5 mM 0.1696 mL 0.8479 mL 1.6957 mL
10 mM 0.0848 mL 0.4239 mL 0.8479 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Homo-PROTAC pVHL30 degrader 1
Cat. No.:
HY-111593
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