1. PROTAC
  2. Ligand for E3 Ligase
    PROTAC

Homo-PROTAC pVHL30 degrader 1 

Cat. No.: HY-111593
Handling Instructions

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.

For research use only. We do not sell to patients.

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

CAS No. : 2244684-49-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].

IC50 & Target

pVHL30[1]
PROTAC[1]

In Vitro

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

References
Molecular Weight

1179.45

Formula

C₅₈H₈₂N₈O₁₄S₂

CAS No.

2244684-49-7

SMILES

CC1=C(C2=CC=C(CNC([[email protected]@H]3C[[email protected]@]([H])(O)CN3C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N4[[email protected]](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[[email protected]@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Homo-PROTAC pVHL30 degrader 1
Cat. No.:
HY-111593
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Homo-PROTAC pVHL30 degrader 1

Cat. No.: HY-111593