2. PROTAC
    Epigenetics
    Apoptosis
  3. PROTACs
    Epigenetic Reader Domain
    Apoptosis
  4. ACBI1

ACBI1 

Cat. No.: HY-128359 Purity: 98.83%
COA Handling Instructions

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis.

For research use only. We do not sell to patients.

ACBI1 Chemical Structure

ACBI1 Chemical Structure

CAS No. : 2375564-55-7

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5 mg USD 290 In-stock
10 mg USD 460 In-stock
50 mg USD 1500 In-stock
100 mg USD 2400 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ACBI1 purchased from MCE. Usage Cited in: Nat Genet. 2023 Mar;55(3):471-483.  [Abstract]

    ACBI1 (1.25, 2.5 μM; 2 days) inhibits ACE2 expression in both Vero E6 and Huh7.5 cells.

    View All PROTACs Isoform Specific Products:

    View All Isoforms
    von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis[1].

    IC50 & Target

    DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]
    In Vitro

    ACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity[1].
    ACBI1 (0.3 µM; 100 h) induces apoptosis in SK-MEL-5 cells[1].
    ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: MV-4-11, NCI-H1568 cells
    Concentration: 0-1000 nM
    Incubation Time: 3-7 days
    Result: Showed anti-proliferative activity with IC50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively.

    Apoptosis Analysis[1]

    Cell Line: SK-MEL-5 cells
    Concentration: 0.3 µM
    Incubation Time: 100 h
    Result: Induced apoptosis in SK-MEL-5 cells.
    Molecular Weight

    936.10

    Appearance

    Solid

    Formula

    C49H58FN9O7S
    CAS No.
    SMILES

    CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (106.83 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0683 mL 5.3413 mL 10.6826 mL
    5 mM 0.2137 mL 1.0683 mL 2.1365 mL
    10 mM 0.1068 mL 0.5341 mL 1.0683 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 98.83%

    COA (254 KB) LCMS (276 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    ACBI12375564-55-7ACBI 1ACBI-1PROTACsEpigenetic Reader DomainApoptosisMV-4-11 cellsSK-MEL-5 cellsanti-proliferativeapoptosisInhibitorinhibitorinhibit

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