1. PROTAC
    Epigenetics
    Apoptosis
  2. PROTAC
    Epigenetic Reader Domain
    Apoptosis
  3. ACBI1

ACBI1 

Cat. No.: HY-128359 Purity: 98.21%
Handling Instructions

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

For research use only. We do not sell to patients.

ACBI1 Chemical Structure

ACBI1 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 8238 In-stock
Estimated Time of Arrival: December 31
1 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 4000 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1].

IC50 & Target

DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]

Molecular Weight

936.10

Formula

C₄₉H₅₈FN₉O₇S

SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (106.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0683 mL 5.3413 mL 10.6826 mL
5 mM 0.2137 mL 1.0683 mL 2.1365 mL
10 mM 0.1068 mL 0.5341 mL 1.0683 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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ACBI1
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HY-128359
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