1. PROTAC
    Epigenetics
    Apoptosis
  2. PROTAC
    Epigenetic Reader Domain
    Apoptosis
  3. ACBI1

ACBI1 

Cat. No.: HY-128359
Handling Instructions

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

For research use only. We do not sell to patients.

ACBI1 Chemical Structure

ACBI1 Chemical Structure

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Description

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1].

IC50 & Target

DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]

Molecular Weight

936.10

Formula

C₄₉H₅₈FN₉O₇S

SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ACBI1
Cat. No.:
HY-128359
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