SMARCA-BD ligand 1 for PROTAC
Based on 1 publication(s) in Google Scholar
SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 1997319-92-2
- Formula: C14H17N5O
- Molecular Weight:271.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SMARCA-BD ligand 1 for PROTAC
MoreAll SWI/SNF Complex Isoforms
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Biological Activity
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SMARCA2 |
SMARCA4 |
PBRM1 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1997319-92-2
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Appearance Solid
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Molecular Weight 271.32
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Formula C14H17N5O
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Color Light yellow to light brown
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SMILES
OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. [Abstract]2024 Oct 1:S2451-9456(24)00396-9. PMID: 39378885
Solvent & Solubility
DMSO : 33.33 mg/mL (122.84 mM; ultrasonic and adjust pH to 6 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.6857 mL | 18.4284 mL | 36.8568 mL | 92.1421 mL |
| 5 mM | 0.7371 mL | 3.6857 mL | 7.3714 mL | 18.4284 mL | |
| 10 mM | 0.3686 mL | 1.8428 mL | 3.6857 mL | 9.2142 mL | |
| 15 mM | 0.2457 mL | 1.2286 mL | 2.4571 mL | 6.1428 mL | |
| 20 mM | 0.1843 mL | 0.9214 mL | 1.8428 mL | 4.6071 mL | |
| 25 mM | 0.1474 mL | 0.7371 mL | 1.4743 mL | 3.6857 mL | |
| 30 mM | 0.1229 mL | 0.6143 mL | 1.2286 mL | 3.0714 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9214 mL | 2.3036 mL | |
| 50 mM | 0.0737 mL | 0.3686 mL | 0.7371 mL | 1.8428 mL | |
| 60 mM | 0.0614 mL | 0.3071 mL | 0.6143 mL | 1.5357 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4607 mL | 1.1518 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9214 mL |
SMARCA-BD ligand 1 for PROTAC Related Classifications
HY-44012 Related Classifications
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