SMARCA-BD ligand 1 for PROTAC
Based on 1 publication(s) in Google Scholar
SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.07%
- No. CAS: 1997319-92-2
- Fòrmula: C14H17N5O
- Peso molecular:271.32
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SMARCA-BD ligand 1 for PROTAC
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
SMARCA2 |
SMARCA4 |
PBRM1 |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1997319-92-2
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Appearance Solid
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Peso molecular 271.32
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Fòrmula C14H17N5O
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Color Light yellow to light brown
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SMILES
OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. [Abstract]2024 Dec 19;31(12):2069-2084.e9. PMID: 39378885
Solvente y solubilidad
In Vitro:
DMSO : 33.33 mg/mL (122.84 mM; ultrasonic and adjust pH to 6 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6857 mL | 18.4284 mL | 36.8568 mL | 92.1421 mL |
| 5 mM | 0.7371 mL | 3.6857 mL | 7.3714 mL | 18.4284 mL | |
| 10 mM | 0.3686 mL | 1.8428 mL | 3.6857 mL | 9.2142 mL | |
| 15 mM | 0.2457 mL | 1.2286 mL | 2.4571 mL | 6.1428 mL | |
| 20 mM | 0.1843 mL | 0.9214 mL | 1.8428 mL | 4.6071 mL | |
| 25 mM | 0.1474 mL | 0.7371 mL | 1.4743 mL | 3.6857 mL | |
| 30 mM | 0.1229 mL | 0.6143 mL | 1.2286 mL | 3.0714 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9214 mL | 2.3036 mL | |
| 50 mM | 0.0737 mL | 0.3686 mL | 0.7371 mL | 1.8428 mL | |
| 60 mM | 0.0614 mL | 0.3071 mL | 0.6143 mL | 1.5357 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4607 mL | 1.1518 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9214 mL |
SMARCA-BD ligand 1 for PROTAC Related Classifications
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