2. PROTAC Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC SWI/SNF Complex
  4. SMARCA-BD ligand 1 for PROTAC dihydrochloride

SMARCA-BD ligand 1 for PROTAC dihydrochloride 

製品番号: HY-44012A 純度: 98.08%
COA 取扱説明書 Technical Support

SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

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SMARCA-BD ligand 1 for PROTAC dihydrochloride

SMARCA-BD ligand 1 for PROTAC dihydrochloride 構造式

CAS 番号 : 2369053-68-7

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $180 在庫あり
10 mg $290 在庫あり
25 mg $490 在庫あり
50 mg $690 在庫あり
100 mg $940 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of SMARCA-BD ligand 1 for PROTAC dihydrochloride:

SMARCA-BD ligand 1 for PROTAC dihydrochloride 関連抗体

Top Publications Citing Use of Products

SWI/SNF Complex アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
SMARCA2 SMARCA4 Protein Polybromo-1

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製品説明

SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

IC50 & Target[1]

SMARCA2

 

SMARCA4

 

PBRM1

 

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMARCA-BD ligand 1 for PROTAC dihydrochloride 関連抗体
分子量

344.24

分子式

C14H19Cl2N5O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 2.7 mg/mL (7.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9050 mL 14.5248 mL 29.0495 mL
5 mM 0.5810 mL 2.9050 mL 5.8099 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9050 mL 14.5248 mL 29.0495 mL 72.6238 mL
5 mM 0.5810 mL 2.9050 mL 5.8099 mL 14.5248 mL
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SMARCA-BD ligand 1 for PROTAC dihydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA-BD ligand 1 for PROTAC2369053-68-7Ligands for Target Protein for PROTACSWI/SNF ComplexTarget Protein-binding MoietySWI/SNF Family of Chromatin-Remodelling ComplexesInhibitorinhibitorinhibit

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製品名:
SMARCA-BD ligand 1 for PROTAC dihydrochloride
製品番号:
HY-44012A
数量:
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