1. PROTAC
  2. Ligand for Target Protein
  3. DUPA

DUPA 

Cat. No.: HY-111606
Handling Instructions

DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells.

For research use only. We do not sell to patients.

DUPA Chemical Structure

DUPA Chemical Structure

CAS No. : 302941-52-2

Size Price Stock
5 mg USD 120 Get quote
10 mg USD 200 Get quote
50 mg USD 750 Get quote
100 mg USD 1200 Get quote

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Description

DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2].

In Vitro

DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer[1]. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures[2].

In Vivo

The DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice[2].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 150 mg/mL (468.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1226 mL 15.6128 mL 31.2256 mL
5 mM 0.6245 mL 3.1226 mL 6.2451 mL
10 mM 0.3123 mL 1.5613 mL 3.1226 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

320.25

Formula

C₁₁H₁₆N₂O₉

CAS No.

302941-52-2

SMILES

O=C(N[[email protected]](CCC(O)=O)([H])C(O)=O)N[[email protected]](CCC(O)=O)([H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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DUPA
Cat. No.:
HY-111606
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DUPA

Cat. No.: HY-111606