SMARCA-BD ligand 1 for PROTAC hydrochloride
Based on 1 publication(s) in Google Scholar
SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 2380272-56-8
- Formula: C14H18ClN5O
- Molecular Weight:307.78
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SMARCA-BD ligand 1 for PROTAC hydrochloride
MoreAll SWI/SNF Complex Isoforms
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Biological Activity
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SMARCA2 |
SMARCA4 |
PBRM1 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2380272-56-8
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Appearance Solid
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Molecular Weight 307.78
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Formula C14H18ClN5O
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Color White to off-white
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SMILES
OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. [Abstract]2024 Dec 19;31(12):2069-2084.e9. PMID: 39378885
Solvent & Solubility
DMSO : 10 mg/mL (32.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2491 mL | 16.2454 mL | 32.4907 mL | 81.2269 mL |
| 5 mM | 0.6498 mL | 3.2491 mL | 6.4981 mL | 16.2454 mL | |
| 10 mM | 0.3249 mL | 1.6245 mL | 3.2491 mL | 8.1227 mL | |
| 15 mM | 0.2166 mL | 1.0830 mL | 2.1660 mL | 5.4151 mL | |
| 20 mM | 0.1625 mL | 0.8123 mL | 1.6245 mL | 4.0613 mL | |
| 25 mM | 0.1300 mL | 0.6498 mL | 1.2996 mL | 3.2491 mL | |
| 30 mM | 0.1083 mL | 0.5415 mL | 1.0830 mL | 2.7076 mL |
SMARCA-BD ligand 1 for PROTAC hydrochloride Related Classifications
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