2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. SMARCA-BD ligand 1 for Protac hydrochloride

SMARCA-BD ligand 1 for Protac hydrochloride 

Cat. No.: HY-44012B Purity: 99.23%
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SMARCA-BD ligand 1 hydrochloride for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

For research use only. We do not sell to patients.

SMARCA-BD ligand 1 for Protac hydrochloride Chemical Structure

SMARCA-BD ligand 1 for Protac hydrochloride Chemical Structure

CAS No. : 2380272-56-8

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Based on 1 publication(s) in Google Scholar

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SMARCA-BD ligand 1 for Protac hydrochloride Related Antibodies

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Description

SMARCA-BD ligand 1 hydrochloride for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

IC50 & Target

SMARCA2[1]
Molecular Weight

307.78

Formula

C14H18ClN5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (32.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2491 mL 16.2454 mL 32.4907 mL
5 mM 0.6498 mL 3.2491 mL 6.4981 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2491 mL 16.2454 mL 32.4907 mL 81.2269 mL
5 mM 0.6498 mL 3.2491 mL 6.4981 mL 16.2454 mL
10 mM 0.3249 mL 1.6245 mL 3.2491 mL 8.1227 mL
15 mM 0.2166 mL 1.0830 mL 2.1660 mL 5.4151 mL
20 mM 0.1625 mL 0.8123 mL 1.6245 mL 4.0613 mL
25 mM 0.1300 mL 0.6498 mL 1.2996 mL 3.2491 mL
30 mM 0.1083 mL 0.5415 mL 1.0830 mL 2.7076 mL
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SMARCA-BD ligand 1 for Protac hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA-BD ligand 1 for Protac2380272-56-8Ligands for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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