1. Cell Cycle/DNA Damage
    PROTAC
  2. APC
    Ligand for Target Protein for PROTAC
  3. Apcin-A

Apcin-A 

Cat. No.: HY-130841
Handling Instructions

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257).

For research use only. We do not sell to patients.

Apcin-A Chemical Structure

Apcin-A Chemical Structure

CAS No. : 1683617-62-0

Size Price Stock
10 mM * 1 mL in DMSO USD 385 Ask For Quote & Lead Time
5 mg USD 350 Ask For Quote & Lead Time
10 mg USD 550 Ask For Quote & Lead Time
25 mg USD 950 Ask For Quote & Lead Time
50 mg USD 1450 Ask For Quote & Lead Time
100 mg USD 2250 Ask For Quote & Lead Time

* Please select Quantity before adding items.

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Description

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257)[1].

Molecular Weight

342.61

Formula

C₁₀H₁₄Cl₃N₅O₂

CAS No.

1683617-62-0

SMILES

O=C(OCCCN)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (291.88 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9188 mL 14.5939 mL 29.1877 mL
5 mM 0.5838 mL 2.9188 mL 5.8375 mL
10 mM 0.2919 mL 1.4594 mL 2.9188 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.30 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Apcin-AAPCLigand for Target Protein for PROTACAnaphase promoting complexTarget Protein-binding MoietysubstratedegradationubiquitinationCdc20interactionInhibitorinhibitorinhibit

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Product Name:
Apcin-A
Cat. No.:
HY-130841
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