1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. CBP/p300 ligand 2

CBP/p300 ligand 2 

Cat. No.: HY-138539 Purity: 98.17%
Handling Instructions

CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

For research use only. We do not sell to patients.

CBP/p300 ligand 2 Chemical Structure

CBP/p300 ligand 2 Chemical Structure

CAS No. : 2484741-78-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 577 Get quote
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 577 Get quote
Solid
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 Get quote
25 mg USD 1800 Get quote
50 mg USD 3000 Get quote
100 mg USD 4600 Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].

In Vitro

CBP/p300 ligand 2 (example 229) has no toxicity to LNCaP prostate cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.61

Formula

C₂₇H₃₄F₂N₈O

CAS No.
SMILES

O=C(N1CCC(N(C2CCNCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (381.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9062 mL 9.5309 mL 19.0618 mL
5 mM 0.3812 mL 1.9062 mL 3.8124 mL
10 mM 0.1906 mL 0.9531 mL 1.9062 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (9.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (9.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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Keywords:

CBP/p300 ligand 2Ligand for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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Product Name:
CBP/p300 ligand 2
Cat. No.:
HY-138539
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