1. PROTAC
  2. Ligands for Target Protein for PROTAC
  3. SirReal1-O-propargyl

SirReal1-O-propargyl (Synonyms: PROTAC Sirt2-binding moiety 1)

Cat. No.: HY-107453
Handling Instructions

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2.

For research use only. We do not sell to patients.

SirReal1-O-propargyl Chemical Structure

SirReal1-O-propargyl Chemical Structure

CAS No. : 1862237-99-7

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10 mM * 1 mL in DMSO USD 605 Ask For Quote & Lead Time
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Description

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1].

IC50 & Target

IC50: 2.4 μM (Sirt2)[1].

Molecular Weight

424.54

Formula

C21H20N4O2S2

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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SirReal1-O-propargyl
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