SirReal1-O-propargyl
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS No.: 1862237-99-7
- Formule: C21H20N4O2S2
- Masse moléculaire:424.54
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-108331
3-TYPSIRT3 Inhibitor -
HY-13515
SirtinolSirtuin Inhibitor -
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SirReal2Sirt2 Inhibitor -
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4'-Bromo-resveratrolSIRT1/SIRT3 Inhibitor -
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AP1867-2-(carboxymethoxy)Ligands for Target Protein for PROTAC -
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JFD00244SIRT2 Inhibitor -
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DUPALigands for Target Protein for PROTAC -
HY-124625
BI-4464PTK2/FAK Inhibitor -
HY-100591R
SirReal2 (Standard)Sirt2 Inhibitor -
HY-111317
SIRT1 activator 3Sirtuin Activator -
HY-107451
PROTAC BET-binding moiety 1Intermediate -
HY-123033A
Nicotinamide riboside chlorideEndogenous Metabolite
Activité biologique
Description
IC50 & Target
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SIRT2 |
Chemical Information
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CAS No. 1862237-99-7
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Appearance Solid
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Masse moléculaire 424.54
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Formule C21H20N4O2S2
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Color White to yellow
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SMILES
O=C(NC1=NC=C(CC2=CC=CC(OCC#C)=C2)S1)CSC3=NC(C)=CC(C)=N3
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Synonyms
PROTAC Sirt2-binding moiety 1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
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Fiche technique (265 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SirReal1-O-propargyl Related Classifications
HY-107453 Related Classifications
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