1. Protein Tyrosine Kinase/RTK PROTAC
  2. FAK Ligands for Target Protein for PROTAC
  3. BI-4464

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.

For research use only. We do not sell to patients.

BI-4464 Chemical Structure

BI-4464 Chemical Structure

CAS No. : 1227948-02-8

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Based on 1 publication(s) in Google Scholar

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Description

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

IC50 & Target

IC50: 17 nM (PTK2/FAK)[1].

Molecular Weight

555.55

Formula

C28H28F3N5O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (30.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8000 mL 9.0001 mL 18.0002 mL
5 mM 0.3600 mL 1.8000 mL 3.6000 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8000 mL 9.0001 mL 18.0002 mL 45.0005 mL
5 mM 0.3600 mL 1.8000 mL 3.6000 mL 9.0001 mL
10 mM 0.1800 mL 0.9000 mL 1.8000 mL 4.5000 mL
15 mM 0.1200 mL 0.6000 mL 1.2000 mL 3.0000 mL
20 mM 0.0900 mL 0.4500 mL 0.9000 mL 2.2500 mL
25 mM 0.0720 mL 0.3600 mL 0.7200 mL 1.8000 mL
30 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5000 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BI-4464
Cat. No.:
HY-124625
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