2. Protein Tyrosine Kinase/RTK PROTAC
  3. FAK Ligands for Target Protein for PROTAC
  4. BI-4464

BI-4464 

Cat. No.: HY-124625 Purity: 99.27%
COA Handling Instructions

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.

For research use only. We do not sell to patients.

BI-4464 Chemical Structure

BI-4464 Chemical Structure

CAS No. : 1227948-02-8

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

BI-4464 Related Antibodies

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Description

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

IC50 & Target

IC50: 17 nM (PTK2/FAK)[1].
Molecular Weight

555.55

Appearance

Solid

Formula

C28H28F3N5O4
CAS No.
SMILES

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (30.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8000 mL 9.0001 mL 18.0002 mL
5 mM 0.3600 mL 1.8000 mL 3.6000 mL
10 mM 0.1800 mL 0.9000 mL 1.8000 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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BI-4464 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BI-44641227948-02-8BI4464BI 4464FAKLigands for Target Protein for PROTACPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseTarget Protein-binding MoietyInhibitorinhibitorinhibit

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