1. Protein Tyrosine Kinase/RTK
    PROTAC
  2. FAK
    Ligand for Target Protein for PROTAC
  3. BI-4464

BI-4464 

Cat. No.: HY-124625 Purity: 98.34%
Handling Instructions

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.

For research use only. We do not sell to patients.

BI-4464 Chemical Structure

BI-4464 Chemical Structure

CAS No. : 1227948-02-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].

IC50 & Target

IC50: 17 nM (PTK2/FAK)[1].

Molecular Weight

555.55

Formula

C₂₈H₂₈F₃N₅O₄

CAS No.

1227948-02-8

SMILES

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (30.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8000 mL 9.0001 mL 18.0002 mL
5 mM 0.3600 mL 1.8000 mL 3.6000 mL
10 mM 0.1800 mL 0.9000 mL 1.8000 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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BI-4464
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HY-124625
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