Dimethyl-F-OICR-9429-COOH
Based on 1 Customer Validation
Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 98.11%
- CAS No.: 2407458-49-3
- Formula: C27H26F4N4O4
- Molecular Weight:546.51
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
Ligand for Target Protein for PROTAC[1]
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2407458-49-3
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Appearance Solid
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Molecular Weight 546.51
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Formula C27H26F4N4O4
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Color Light brown to brown
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SMILES
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@@H](N([C@@H](C3)C)C)C)C=CC(C4=CC(C(O)=O)=CC=C4F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (365.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8298 mL | 9.1490 mL | 18.2979 mL | 45.7448 mL |
| 5 mM | 0.3660 mL | 1.8298 mL | 3.6596 mL | 9.1490 mL | |
| 10 mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 4.5745 mL | |
| 15 mM | 0.1220 mL | 0.6099 mL | 1.2199 mL | 3.0497 mL | |
| 20 mM | 0.0915 mL | 0.4574 mL | 0.9149 mL | 2.2872 mL | |
| 25 mM | 0.0732 mL | 0.3660 mL | 0.7319 mL | 1.8298 mL | |
| 30 mM | 0.0610 mL | 0.3050 mL | 0.6099 mL | 1.5248 mL | |
| 40 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1436 mL | |
| 50 mM | 0.0366 mL | 0.1830 mL | 0.3660 mL | 0.9149 mL | |
| 60 mM | 0.0305 mL | 0.1525 mL | 0.3050 mL | 0.7624 mL | |
| 80 mM | 0.0229 mL | 0.1144 mL | 0.2287 mL | 0.5718 mL | |
| 100 mM | 0.0183 mL | 0.0915 mL | 0.1830 mL | 0.4574 mL |
Dimethyl-F-OICR-9429-COOH Related Classifications
HY-141799 Related Classifications
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