Dimethyl-F-OICR-9429-COOH

Name: Dimethyl-F-OICR-9429-COOH
Brand: MedChemExpress
SKU: HY-141799
Rating: 4.5 (0 reviews)

Cat. No.: HY-141799 Pureza: 98.11%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs.

Para uso exclusivo en investigación. No vendemos a pacientes.

Dimethyl-F-OICR-9429-COOH Estructura química

No. CAS : 2407458-49-3

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Ligand for Target Protein for PROTAC^[1]

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

546.51

Fòrmula

C₂₇H₂₆F₄N₄O₄

No. CAS

2407458-49-3

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@@H](N([C@@H](C3)C)C)C)C=CC(C4=CC(C(O)=O)=CC=C4F)=C2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 200 mg/mL (365.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8298 mL	9.1490 mL	18.2979 mL
5 mM	0.3660 mL	1.8298 mL	3.6596 mL
10 mM	0.1830 mL	0.9149 mL	1.8298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.11%

Select Batch:

Ficha de datos (276 KB) SDS (480 KB)

COA (256 KB) HNMR (391 KB) LCMS (104 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8298 mL	9.1490 mL	18.2979 mL	45.7448 mL
	5 mM	0.3660 mL	1.8298 mL	3.6596 mL	9.1490 mL
	10 mM	0.1830 mL	0.9149 mL	1.8298 mL	4.5745 mL
	15 mM	0.1220 mL	0.6099 mL	1.2199 mL	3.0497 mL
	20 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	25 mM	0.0732 mL	0.3660 mL	0.7319 mL	1.8298 mL
	30 mM	0.0610 mL	0.3050 mL	0.6099 mL	1.5248 mL
	40 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	50 mM	0.0366 mL	0.1830 mL	0.3660 mL	0.9149 mL
	60 mM	0.0305 mL	0.1525 mL	0.3050 mL	0.7624 mL
	80 mM	0.0229 mL	0.1144 mL	0.2287 mL	0.5718 mL
	100 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.4574 mL