Dimethyl-F-OICR-9429-COOH

Name: Dimethyl-F-OICR-9429-COOH
Brand: MedChemExpress
SKU: HY-141799
Rating: 4.5 (0 reviews)

製品番号: HY-141799 純度: 98.11%: Data Sheet SDS COA 取扱説明書
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Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Dimethyl-F-OICR-9429-COOH 構造式

CAS 番号 : 2407458-49-3

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 481	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 481	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$400	在庫あり	Estimated Time of Arrival: December 31
10 mg	$680	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1350	在庫あり	Estimated Time of Arrival: December 31
50 mg	$2200	在庫あり	Estimated Time of Arrival: December 31
100 mg	$3400	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Ligand for Target Protein for PROTAC^[1]

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

546.51

分子式

C₂₇H₂₆F₄N₄O₄

CAS 番号

2407458-49-3

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@@H](N([C@@H](C3)C)C)C)C=CC(C4=CC(C(O)=O)=CC=C4F)=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 200 mg/mL (365.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8298 mL	9.1490 mL	18.2979 mL
5 mM	0.3660 mL	1.8298 mL	3.6596 mL
10 mM	0.1830 mL	0.9149 mL	1.8298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.11%

Select Batch:

データシート (276 KB) SDS (480 KB)

COA (256 KB) HNMR (391 KB) LCMS (104 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8298 mL	9.1490 mL	18.2979 mL	45.7448 mL
	5 mM	0.3660 mL	1.8298 mL	3.6596 mL	9.1490 mL
	10 mM	0.1830 mL	0.9149 mL	1.8298 mL	4.5745 mL
	15 mM	0.1220 mL	0.6099 mL	1.2199 mL	3.0497 mL
	20 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	25 mM	0.0732 mL	0.3660 mL	0.7319 mL	1.8298 mL
	30 mM	0.0610 mL	0.3050 mL	0.6099 mL	1.5248 mL
	40 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	50 mM	0.0366 mL	0.1830 mL	0.3660 mL	0.9149 mL
	60 mM	0.0305 mL	0.1525 mL	0.3050 mL	0.7624 mL
	80 mM	0.0229 mL	0.1144 mL	0.2287 mL	0.5718 mL
	100 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.4574 mL