2. PROTAC
  3. Ligands for E3 Ligase
  4. VH032-cyclopropane-F

VH032-cyclopropane-F  (Synonyms: VHL ligand 3; E3 ligase Ligand 19)

Cat. No.: HY-125905 Purity: 99.39%
COA Handling Instructions

VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.

For research use only. We do not sell to patients.

VH032-cyclopropane-F Chemical Structure

VH032-cyclopropane-F Chemical Structure

CAS No. : 2306193-99-5

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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE VH032-cyclopropane-F

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1].

IC50 & Target

VHL

 

Molecular Weight

532.63

Appearance

Solid

Formula

C26H33FN4O5S
CAS No.
SMILES

O=C(NCC1=CC=C(C=C1O)C2=C(N=CS2)C)[[email protected]]3N(C[[email protected]@H](C3)O)C([[email protected]](C(C)(C)C)NC(C4(CC4)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (187.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8775 mL 9.3874 mL 18.7748 mL
5 mM 0.3755 mL 1.8775 mL 3.7550 mL
10 mM 0.1877 mL 0.9387 mL 1.8775 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.69 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.39%

COA (260 KB) HNMR (225 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

VH032-cyclopropane-F2306193-99-5VHL ligand 3 E3 ligase Ligand 19VHL ligand3VHL ligand-3Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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