1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-Me hydrochloride (Synonyms: VHL ligand 2 hydrochloride; E3 ligase Ligand 1)

Cat. No.: HY-42424 Purity: 98.19%
Handling Instructions

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me hydrochloride Chemical Structure

(S,R,S)-AHPC-Me hydrochloride Chemical Structure

CAS No. : 1948273-03-7

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Based on 1 publication(s) in Google Scholar

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Description

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].

IC50 & Target

VHL

 

Molecular Weight

481.05

Formula

C₂₃H₃₃ClN₄O₃S

CAS No.

1948273-03-7

SMILES

N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(N[[email protected]@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 63 mg/mL (130.96 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0788 mL 10.3939 mL 20.7879 mL
5 mM 0.4158 mL 2.0788 mL 4.1576 mL
10 mM 0.2079 mL 1.0394 mL 2.0788 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.19%

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Keywords:

(S,R,S)-AHPC-MeVHL ligand 2E3 ligase Ligand 1VHL ligand2VHL ligand-2Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Product name:
(S,R,S)-AHPC-Me hydrochloride
Cat. No.:
HY-42424
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