1. PROTAC
  2. Ligands for E3 Ligase
  3. (S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-Me hydrochloride (Synonyms: VHL ligand 2 hydrochloride; E3 ligase Ligand 1)

Cat. No.: HY-42424 Purity: 98.58%
Handling Instructions

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me hydrochloride Chemical Structure

(S,R,S)-AHPC-Me hydrochloride Chemical Structure

CAS No. : 1948273-03-7

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Estimated Time of Arrival: December 31
2 g USD 1800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-Me hydrochloride:

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Description

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].

IC50 & Target

VHL

 

Molecular Weight

481.05

Formula

C23H33ClN4O3S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (207.88 mM; Need ultrasonic)

DMSO : ≥ 63 mg/mL (130.96 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0788 mL 10.3939 mL 20.7879 mL
5 mM 0.4158 mL 2.0788 mL 4.1576 mL
10 mM 0.2079 mL 1.0394 mL 2.0788 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.32 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 98.58%

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Product Name:
(S,R,S)-AHPC-Me hydrochloride
Cat. No.:
HY-42424
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