1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC-Me

(S,R,S)-AHPC-Me (Synonyms: VHL ligand 2; E3 ligase Ligand 1A)

Cat. No.: HY-112078
Handling Instructions

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me Chemical Structure

(S,R,S)-AHPC-Me Chemical Structure

CAS No. : 1948273-02-6

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Description

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].

IC50 & Target

VHL

 

Molecular Weight

444.59

Formula

C₂₃H₃₂N₄O₃S

CAS No.

1948273-02-6

SMILES

N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(N[[email protected]@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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(S,R,S)-AHPC-Me
Cat. No.:
HY-112078
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