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Cat. No.: HY-103597R

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Thalidomide-O-COOH (Standard)

(Synonyms: Cereblon ligand 3 (Standard); E3 ligase Ligand 3 (Standard))

Thalidomide-O-COOH (Standard) is the analytical standard of Thalidomide-O-COOH (HY-103597). This product is intended for research and analytical applications. Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

CAS No.: 1061605-21-7
Formula: C₁₅H₁₂N₂O₇
Molecular Weight:332.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thalidomide-O-COOH (Standard) Chemical Structure

CAS No.: 1061605-21-7

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1061605-21-7
Molecular Weight 332.27
Formula C₁₅H₁₂N₂O₇
SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O
Synonyms

Cereblon ligand 3 (Standard); E3 ligase Ligand 3 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bozilovic J, et al. Novel, highly potent PROTACs targeting AURORA-A kinase. Current Research in Chemical Biology. 2022, 2: 100032.

[2]. Yamanaka S, et al. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun. 2023 Aug 18;14(1):4683. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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