1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,S,S)-AHPC hydrochloride

(S,S,S)-AHPC hydrochloride (Synonyms: (S,S,S)-VH032-NH2 hydrochloride)

Cat. No.: HY-125845A
Handling Instructions

(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein.

For research use only. We do not sell to patients.

(S,S,S)-AHPC hydrochloride Chemical Structure

(S,S,S)-AHPC hydrochloride Chemical Structure

CAS No. : 2115897-23-7

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Description

(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

IC50 & Target[1]

VHL

 

In Vitro

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

Molecular Weight

467.02

Formula

C₂₂H₃₁ClN₄O₃S

CAS No.

2115897-23-7

SMILES

O=C([[email protected]](C[[email protected]](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(S,S,S)-AHPC(S,S,S)-VH032-NH2Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Product name:
(S,S,S)-AHPC hydrochloride
Cat. No.:
HY-125845A
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