1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide-5-OH

Thalidomide-5-OH 

Cat. No.: HY-23095 Purity: >98.0%
Handling Instructions

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

Thalidomide-5-OH Chemical Structure

Thalidomide-5-OH Chemical Structure

CAS No. : 64567-60-8

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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

274.23

Formula

C₁₃H₁₀N₂O₅

CAS No.

64567-60-8

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (227.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6466 mL 18.2329 mL 36.4657 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL
10 mM 0.3647 mL 1.8233 mL 3.6466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide-5-OHLigand for E3 LigaseE3 ligase-recruiting MoietyThalidomideCRBNPROTACInhibitorinhibitorinhibit

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Product Name:
Thalidomide-5-OH
Cat. No.:
HY-23095
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