1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide 5-fluoride

Thalidomide 5-fluoride 

Cat. No.: HY-W087383 Purity: 99.03%
Handling Instructions

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

For research use only. We do not sell to patients.

Thalidomide 5-fluoride Chemical Structure

Thalidomide 5-fluoride Chemical Structure

CAS No. : 835616-61-0

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Free Sample (0.5-1 mg)   Apply Now  
100 mg USD 75 In-stock
Estimated Time of Arrival: December 31
250 mg USD 150 In-stock
Estimated Time of Arrival: December 31
500 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide 5-fluoride:

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Description

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

IC50 & Target

Cereblon

 

Molecular Weight

276.22

Formula

C₁₃H₉FN₂O₄

CAS No.

835616-61-0

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (301.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6203 mL 18.1015 mL 36.2030 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL
10 mM 0.3620 mL 1.8102 mL 3.6203 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

Thalidomide 5-fluorideLigand for E3 LigaseE3 ligase-recruiting MoietyIRAK4 proteinprotacInhibitorinhibitorinhibit

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Product Name:
Thalidomide 5-fluoride
Cat. No.:
HY-W087383
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