2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide 5-fluoride

Thalidomide 5-fluoride 

Cat. No.: HY-W087383 Purity: 99.85%
COA Handling Instructions

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

For research use only. We do not sell to patients.

Thalidomide 5-fluoride Chemical Structure

Thalidomide 5-fluoride Chemical Structure

CAS No. : 835616-61-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
1 g USD 30 In-stock
Estimated Time of Arrival: December 31
5 g USD 120 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide 5-fluoride:

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

IC50 & Target

Cereblon

 

Molecular Weight

276.22

Appearance

Solid

Formula

C13H9FN2O4
CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (301.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6203 mL 18.1015 mL 36.2030 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL
10 mM 0.3620 mL 1.8102 mL 3.6203 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.85%

COA (249 KB) HNMR (120 KB) LCMS (244 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide 5-fluoride835616-61-0Ligands for E3 LigaseE3 ligase-recruiting MoietyLigand for E3 LigaseIRAK4 proteinprotacInhibitorinhibitorinhibit

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