1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide fluoride

Thalidomide fluoride (Synonyms: Cereblon ligand 4; E3 ligase Ligand 4)

Cat. No.: HY-41547 Purity: 98.77%
Handling Instructions

Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

For research use only. We do not sell to patients.

Thalidomide fluoride Chemical Structure

Thalidomide fluoride Chemical Structure

CAS No. : 835616-60-9

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Description

Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].

IC50 & Target

Cereblon

 

Molecular Weight

276.22

Formula

C₁₃H₉FN₂O₄

CAS No.

835616-60-9

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (724.06 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6203 mL 18.1015 mL 36.2030 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL
10 mM 0.3620 mL 1.8102 mL 3.6203 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.77%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Thalidomide fluorideCereblon ligand 4E3 ligase Ligand 4Cereblon ligand4Cereblon ligand-4Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Product name:
Thalidomide fluoride
Cat. No.:
HY-41547
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