1. PROTAC
  2. Ligands for E3 Ligase
  3. Thalidomide 4-fluoride

Thalidomide 4-fluoride (Synonyms: Cereblon ligand 4; E3 ligase Ligand 4)

Cat. No.: HY-41547 Purity: 99.20%
Handling Instructions

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

For research use only. We do not sell to patients.

Thalidomide 4-fluoride Chemical Structure

Thalidomide 4-fluoride Chemical Structure

CAS No. : 835616-60-9

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Estimated Time of Arrival: December 31
50 mg USD 88 In-stock
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100 mg USD 121 In-stock
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500 mg USD 231 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].

IC50 & Target

Cereblon

 

Molecular Weight

276.22

Formula

C13H9FN2O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (724.06 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6203 mL 18.1015 mL 36.2030 mL
5 mM 0.7241 mL 3.6203 mL 7.2406 mL
10 mM 0.3620 mL 1.8102 mL 3.6203 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.31%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Thalidomide 4-fluoride
Cat. No.:
HY-41547
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