Thalidomide 4-fluoride
Based on 1 Customer Validation
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 835616-60-9
- Formula: C13H9FN2O4
- Molecular Weight:276.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon |
Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4). Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 835616-60-9
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Appearance Solid
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Molecular Weight 276.22
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Formula C13H9FN2O4
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Color Off-white to gray
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O
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Synonyms
Cereblon ligand 4; E3 ligase Ligand 4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 200 mg/mL (724.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6203 mL | 18.1013 mL | 36.2026 mL | 90.5066 mL |
| 5 mM | 0.7241 mL | 3.6203 mL | 7.2405 mL | 18.1013 mL | |
| 10 mM | 0.3620 mL | 1.8101 mL | 3.6203 mL | 9.0507 mL | |
| 15 mM | 0.2414 mL | 1.2068 mL | 2.4135 mL | 6.0338 mL | |
| 20 mM | 0.1810 mL | 0.9051 mL | 1.8101 mL | 4.5253 mL | |
| 25 mM | 0.1448 mL | 0.7241 mL | 1.4481 mL | 3.6203 mL | |
| 30 mM | 0.1207 mL | 0.6034 mL | 1.2068 mL | 3.0169 mL | |
| 40 mM | 0.0905 mL | 0.4525 mL | 0.9051 mL | 2.2627 mL | |
| 50 mM | 0.0724 mL | 0.3620 mL | 0.7241 mL | 1.8101 mL | |
| 60 mM | 0.0603 mL | 0.3017 mL | 0.6034 mL | 1.5084 mL | |
| 80 mM | 0.0453 mL | 0.2263 mL | 0.4525 mL | 1.1313 mL | |
| 100 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9051 mL |
Thalidomide 4-fluoride Related Classifications
HY-41547 Related Classifications
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