835616-60-9
835616-60-9
Chemical Structure
Thalidomide 4-fluoride
Synonym(s): Cereblon ligand 4; E3 ligase Ligand 4
- CAS No.: 835616-60-9
- Formula:C13H9FN2O4
- Molecular Weight:276.22
IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
InChIKey: CRAUTELYXAAAPW-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O
Biological Activity: Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thalidomide 4-fluoride | 99.83% | Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966). | ||||||||||||||||||||
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References
Keywords
