Thalidomide-4-F,5-Br
Based on 1 Customer Validation
Thalidomide-4-F,5-Br is a Thalidomide analogue. Thalidomide recruits E3 ligase for the ubiquitinylation and subsequent proteolysis of a target protein. This molecule may be derivatized through substitution at fluorine or bromine.
For research use only. We do not sell to patients.
- Purity : 99.37%
- CAS No.: 2740657-28-5
- Formula: C13H8BrFN2O4
- Molecular Weight:355.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cereblon |
Chemical Information
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CAS No. 2740657-28-5
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Appearance Solid
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Molecular Weight 355.12
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Formula C13H8BrFN2O4
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Color Off-white to light yellow
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SMILES
O=C1NC(C(CC1)N2C(C3=CC=C(C(F)=C3C2=O)Br)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (140.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8159 mL | 14.0797 mL | 28.1595 mL | 70.3987 mL |
| 5 mM | 0.5632 mL | 2.8159 mL | 5.6319 mL | 14.0797 mL | |
| 10 mM | 0.2816 mL | 1.4080 mL | 2.8159 mL | 7.0399 mL | |
| 15 mM | 0.1877 mL | 0.9386 mL | 1.8773 mL | 4.6932 mL | |
| 20 mM | 0.1408 mL | 0.7040 mL | 1.4080 mL | 3.5199 mL | |
| 25 mM | 0.1126 mL | 0.5632 mL | 1.1264 mL | 2.8159 mL | |
| 30 mM | 0.0939 mL | 0.4693 mL | 0.9386 mL | 2.3466 mL | |
| 40 mM | 0.0704 mL | 0.3520 mL | 0.7040 mL | 1.7600 mL | |
| 50 mM | 0.0563 mL | 0.2816 mL | 0.5632 mL | 1.4080 mL | |
| 60 mM | 0.0469 mL | 0.2347 mL | 0.4693 mL | 1.1733 mL | |
| 80 mM | 0.0352 mL | 0.1760 mL | 0.3520 mL | 0.8800 mL | |
| 100 mM | 0.0282 mL | 0.1408 mL | 0.2816 mL | 0.7040 mL |
Thalidomide-4-F,5-Br Related Classifications
HY-W453715 Related Classifications
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